A Phase I–II study in the use of acupuncture-like transcutaneous nerve stimulation in the treatment of radiation-induced xerostomia in head-and-neck cancer patients treated with radical radiotherapy

Wong, Raimond; Jones, Glenn; Sagar, Stephen M.; Babjak, Angelica-Fargas; Whelan, Timothy J.

doi:10.1016/s0360-3016(03)00572-8

Cited by 123 publications

(116 citation statements)

References 27 publications

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“…At the end of the 1990s, there was a small but steady increase, a development that has been accentuated in the last 10 years. according to phase I (Singh et al, 2008;Mazetto et al, 2007;Kim et al, 2004;Zeltzer et al, 2002), and another four according to phase II (Beer et al, 2010;Lansdown et al, 2009;Vickers et al, 2004;Wong et al, 2003). A relevant question is if this growth is larger than the general increase of published items on acupuncture?…”

Section: Clinical Trialsmentioning

confidence: 99%

Development of Scientific Publications on Acupuncture

Danell¹,

Danell²

2011

Acupuncture - Concepts and Physiology

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Section: Clinical Trialsmentioning

confidence: 99%

Development of Scientific Publications on Acupuncture

Danell¹,

Danell²

2011

Acupuncture - Concepts and Physiology

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“…At the Juravinski Cancer Centre in Ontario, Canada, a combined phase I and II study of AL-TENS in the treatment of radiation-induced xerostomia was carried out 287 . The 45 participating patients were randomized into three treatment groups that received Codetron AL-TENS stimulation to one of three different sets of acupuncture points:…”

Section: Acupuncturementioning

confidence: 99%

Chinese Medicine and Biomodulation in Cancer Patients—Part Two

Sagar

Wong

2008

Current Oncology

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Traditional Chinese Medicine (TCM) is a whole system containing therapeutic interventions that individually induce biomodulation at the physiologic, chemical, and molecular levels. The theory of TCM proposes a synergy between specific interventions selected as part of a care plan based on TCM diagnostic theory. Combining TCM with the modern practice of oncology seems, in conjunction with biomedical interventions (surgery, radiotherapy, chemotherapy, and pharmaceuticals), to have potential advantages through the synergy of biomodulation. Biomodulation approaches are broadly categorized as modification of tumour response and reduction of adverse effects; modulation of immunity; prevention of cancer progression; and enhancement of symptom control. Although the database of preclinical studies is rapidly expanding, good-quality clinical trials are notably scarce.Laboratory studies suggest that some herbs increase the effectiveness of conventional chemotherapy without increasing toxicity. A healthy immune system is necessary for control of malignant disease, and the immune suppression associated with cancer contributes to its progression. Many Chinese herbs contain glycoproteins and polysaccharides (among them, constituents of Coriolus versicolor, Ganoderma lucidum, Grifola frondosa, Astragalus membranaceus, Panax ginseng, and various other medicinal mushrooms) that can modulate metastatic potential and the innate immune system. Phytochemicals such as specific polysaccharides have been shown to boost the innate immune system, especially through interaction with Tolllike receptors in mucosa-associated lymphoid tissue. This intervention can potentially improve the effectiveness of new anticancer vaccines. An increase in virusassociated cancers presents a major public health problem that requires novel therapeutic strategies. A number of herbal therapies have both antiviral activity and the ability to promote immunity, possibly inhibiting the initiation and promotion of virus-associated cancers.The mechanisms learned from basic science should be applied to clinical trials both of specific interventions and of whole-system care plans that safely combine the TCM approach with the conventional biomedical model. In Western medicine, the combination of TCM herbs with drug therapies is controversial, given lack of knowledge concerning whether a drug is favourably enhanced or whether adverse effects occur. Using initial data from the preclinical studies, future clinical research needs to evaluate the combinations, some of which are showing favourable synergy.

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“…If some salivary function is preserved after radical radiotherapy, salivary secretion can be stimulated with drugs, acidic candy, or chewing gum [58]. Acupuncture has been tested, but with no proven benefit [59]. Furthermore, xerostomia can partially be prevented using amifostine, a radioprotectant with a relative specificity to normal tissues, but with a high degree of acute side effects [60].…”

Section: Dry Mouthmentioning

confidence: 99%

Measuring side effects after radiotherapy for pharynx cancer

Jensen

2007

Acta Oncologica

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A Phase I–II study in the use of acupuncture-like transcutaneous nerve stimulation in the treatment of radiation-induced xerostomia in head-and-neck cancer patients treated with radical radiotherapy

Cited by 123 publications

References 27 publications

Development of Scientific Publications on Acupuncture

Development of Scientific Publications on Acupuncture

Chinese Medicine and Biomodulation in Cancer Patients—Part Two

Measuring side effects after radiotherapy for pharynx cancer

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