A phase diagram structure determines the optimal sensitivity-precision trade-off in signaling systems
Ka Kit Kong,
Chunxiong Luo,
Feng Liu
Abstract:Signal transduction is crucial for many biological functions. However, it is still unclear how signaling systems function accurately under noisy situations. More specifically, such systems operate in a regime of low response noise, while maintaining high sensitivity to signals. To gain further insight on this regime, here we derive a fundamental trade-off between response sensitivity and precision in biological signaling processes under the static noise condition. We find that the optimal trade-off in signalin… Show more
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