A phase 2 randomized controlled trial of oral resistant starch supplements in the prevention of acute radiation proctitis in patients treated for cervical cancer

Sasidharan, Balu Krishna; Balamurugan, Ramadass; Viswanathan, Prakash; Samuel, Prasanna; Gowri, Mahasampath; Pugazhendhi, Srinivasan; Ramakrishna, Balakrishnan S.

doi:10.4103/jcrt.jcrt_152_19

Cited by 24 publications

(37 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It should be noted, however, that not all dietary approaches have proven to be successful in reducing the incidence of GI complications following anti-cancer radiotherapy. For example, a clinical trial that studied oral starch supplements to reduce radiation proctitis did not meet its primary endpoint in patients irradiated for cervical cancer ( Sasidharan et al, 2019 ). Furthermore, in a mouse model of lethal radiation exposure, mice that received dietary supplementation with methionine were found to be more sensitive to GI-ARS ( Miousse et al, 2020 ).…”

Section: The Effects Of the Microbiome On The Radiation Responsementioning

confidence: 99%

Acute Radiation Syndrome and the Microbiome: Impact and Review

et al. 2021

View full text Add to dashboard Cite

Study of the human microbiota has been a centuries-long endeavor, but since the inception of the National Institutes of Health (NIH) Human Microbiome Project in 2007, research has greatly expanded, including the space involving radiation injury. As acute radiation syndrome (ARS) is multisystemic, the microbiome niches across all areas of the body may be affected. This review highlights advances in radiation research examining the effect of irradiation on the microbiome and its potential use as a target for medical countermeasures or biodosimetry approaches, or as a medical countermeasure itself. The authors also address animal model considerations for designing studies, and the potential to use the microbiome as a biomarker to assess radiation exposure and predict outcome. Recent research has shown that the microbiome holds enormous potential for mitigation of radiation injury, in the context of both radiotherapy and radiological/nuclear public health emergencies. Gaps still exist, but the field is moving forward with much promise.

show abstract

Section: The Effects Of the Microbiome On The Radiation Responsementioning

confidence: 99%

Acute Radiation Syndrome and the Microbiome: Impact and Review

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Recent years have seen multiple preclinical and clinical studies showing the benefits of prebiotics, but it is important to remember that "one size does not fit all." Oral prebiotic amylase-resistant starch does not prevent acute radiation proctitis in patients with cervical cancer when given in conjunction with chemotherapy (93). But a prebiotic regimen containing fructooligosaccharides, xylooligosaccharides, polydextrose, and resistant dextrin improves serum immunologic indicators and reverses surgical stress-induced increase in opportunistic pathogens in patients with colorectal cancer when given 7 days prior to surgery (85).…”

Section: Microbiota Modulations As Adjuvant Cancer Therapymentioning

confidence: 99%

The Microbiome and Cancer: Creating Friendly Neighborhoods and Removing the Foes Within

Parida

Sharma

2021

Cancer Research

View full text Add to dashboard Cite

The human body is colonized by the microbial cells that are estimated to be as abundant as human cells, yet their genome is roughly 100 times the human genome, providing significantly more genetic diversity. The past decade has observed an explosion of interest in examining the existence of microbiota in the human body and understanding its role in various diseases including inflammatory bowel disease, neurologic diseases, cardiovascular disorders, and cancer. Many studies have demonstrated differential community composition between normal tissue and cancerous tissue, paving the way for investigations focused on deciphering the cause-and-effect relationships between specific microbes and initiation and progression of various cancers. Also, evolving are the strategies to alter tumor-associated dysbiosis and move it toward eubiosis with holistic approaches to change the entire neighborhood or to neutralize pathogenic strains. In this review, we discuss important pathogenic bacteria and the underlying mechanisms by which they affect cancer progression. We summarize key microbiota alterations observed in multiple tumor niches, their association with clinical stages, and their potential use in cancer diagnosis and management. Finally, we discuss microbiota-based therapeutic approaches.

show abstract

“…As seen in Figure 2, probiotic treatment was found to significantly improve several GI and some psychosocial health outcomes (ie, QOL) in cancer patients and survivors. In total, 11 studies investigated the effects of a prebiotic, 42,43 probiotic, [38][39][40][41]44,46,48 or synbiotic 37,47 treatment on GI outcomes. As seen in Table 1, a variety of measures were used to evaluate GI symptoms.…”

Section: Intervention Effects On Gastrointestinal and Mental Health Outcomesmentioning

confidence: 99%

“…Ten of the included studies utilized a randomized controlled trial design. [37][38][39][40][42][43][44][45]47,48 Two studies utilized a pre-post, single-group design. 41,46 Despite small sample sizes in some studies, 7 of these studies [37][38][39][40]43,47,48 were methodologically sound resulting in scores ranging from 100% to 79% and a rating of "good."…”

Section: Study Quality Assessmentmentioning

confidence: 99%

“…[37][38][39][40][42][43][44][45]47,48 Two studies utilized a pre-post, single-group design. 41,46 Despite small sample sizes in some studies, 7 of these studies [37][38][39][40]43,47,48 were methodologically sound resulting in scores ranging from 100% to 79% and a rating of "good." Two of the RCTs 42,45 , one pre-post single group study 41 only met some of the criteria and thus received a rating of "fair."…”

Section: Study Quality Assessmentmentioning

confidence: 99%

See 1 more Smart Citation

The Use of Prebiotic and Probiotic Interventions for Treating Gastrointestinal and Psychosocial Health Symptoms in Cancer Patients and Survivors: A Systematic Review

et al. 2021

View full text Add to dashboard Cite

Background: Cancer treatments can cause significant gastrointestinal (GI) health issues, and negatively affect patient’s psychosocial health and quality of life (QOL). Novel, integrative strategies using prebiotics and probiotics have been explored for treating adverse cancer treatment-related side effects. We evaluated the current literature for interventions using prebiotics or probiotics specifically to treat GI and psychosocial health issues in cancer patients and survivors. Methods: Five databases (PubMed, MEDLINE (Ovid), CINHAL, PsychINFO, Web of Science) were searched for studies with prebiotic or probiotic interventions where GI and/or psychosocial health outcomes were measured in adult cancer patients and survivors, and published before September 12th 2021. Results: Twelve studies (N = 974 participants) meeting the inclusion criteria were identified (randomized controlled trials [n = 10], single-group pre-post studies [n = 2]). Ten studies were conducted with patients on active cancer treatment, and 2 studies treated patients after anti-cancer therapies. Three studies used prebiotics, 7 studies used probiotics, and 2 studies used a combination therapy. The most commonly used probiotic strains were from the Lactobacillus genus. There was minimal evidence for prebiotics to improve GI or psychosocial health. Probiotics were associated with significant improvements in abdominal pain (n = 2), gas/bloating (n = 2), and especially diarrhea (n = 5), and with improvements in anxiety (n = 1), depression (n = 1), fatigue (n = 1), and QOL (n = 2). Conclusions: Studies specifically examining effects of prebiotics and probiotics on GI and psychosocial health outcomes are scarce. Probiotic intervention may improve some GI symptoms in cancer patients, and QOL in survivors. Controlled trials that consistently include GI and psychosocial health outcomes are needed.

show abstract

A phase 2 randomized controlled trial of oral resistant starch supplements in the prevention of acute radiation proctitis in patients treated for cervical cancer

Cited by 24 publications

References 1 publication

Acute Radiation Syndrome and the Microbiome: Impact and Review

Acute Radiation Syndrome and the Microbiome: Impact and Review

The Microbiome and Cancer: Creating Friendly Neighborhoods and Removing the Foes Within

The Use of Prebiotic and Probiotic Interventions for Treating Gastrointestinal and Psychosocial Health Symptoms in Cancer Patients and Survivors: A Systematic Review

Contact Info

Product

Resources

About