A pharmacological analysis of food intake regulation in rats treated neonatally with monosodium L-glutamate (MSG)

Dawson, Ralph; Wallace, David R.; Gabriel, Steven M.

doi:10.1016/0091-3057(89)90168-8

Cited by 36 publications

(15 citation statements)

References 45 publications

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“…Obese hyperinsulinemic rodents, with a genetic defect related to the ARC function, such as Zucker rats, and ob/ob and db/db mice, manifested hyperphagia (Olney 1969, Brayman et al 1992. However, present data show that MSG mice do not increase food intake, corroborating previous literature (Dawson et al 1989, Balbo et al 2000. Although MSG mice manifest normophagia, increased fat is accumulated in their periepididymal pads.…”

Section: Discussionsupporting

confidence: 82%

Swimming exercise at weaning improves glycemic control and inhibits the onset of monosodium l-glutamate-obesity in mice

Andreazzi¹,

Scomparin²,

Mesquita³

et al. 2009

Journal of Endocrinology

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Swimming exercises by weaning pups inhibited hypothalamic obesity onset and recovered sympathoadrenal axis activity, but this was not observed when exercise training was applied to young adult mice. However, the mechanisms producing this improved metabolism are still not fully understood. Low-intensity swimming training started at an early age and was undertaken to observe glycemic control in hypothalamic-obese mice produced by neonatal treatment with monosodium L-glutamate (MSG). Whereas MSG and control mice swam for 15 min/day, 3 days a week, from the weaning stage up to 90 days old, sedentary MSG and normal mice did not exercise at all. After 14 h of fasting, animals were killed at 90 days of age. Perigonadal fat accumulation was measured to estimate obesity. Fasting blood glucose and insulin concentrations were also measured. Fresh isolated pancreatic islets were used to test glucose-induced insulin release and total catecholamine from the adrenal glands was measured. Mice were also submitted to intraperitoneal glucose tolerance test. MSG-obese mice showed fasting hyperglycemia, hyperinsulinemia, and glucose intolerance. Severe reduction of adrenal catecholamines content has also been reported. Besides, the inhibition of fat tissue accretion, exercise caused normalization of insulin blood levels and glycemic control. The pancreatic islets of obese mice, with impaired glucose-induced insulin secretion, were recovered after swimming exercises. Adrenal catecholamine content was increased by swimming. Results show that attenuation of MSG-hypothalamic obesity onset is caused, at least in part, by modulation of sympathoadrenal axis activity imposed by early exercise, which may be associated with subsequent glucose metabolism improvement.

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Section: Discussionsupporting

confidence: 82%

Swimming exercise at weaning improves glycemic control and inhibits the onset of monosodium l-glutamate-obesity in mice

Andreazzi¹,

Scomparin²,

Mesquita³

et al. 2009

Journal of Endocrinology

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“…An experimental model of hypothalamic obesity, caused by the neonatal administration of monosodium glutamate [18,32], has also been studied [16]. It has been verified that the metabolic alterations caused by partial lipectomy were more intense in the hypothalamic obese rats, in comparison to those found in the normal ones.…”

Section: Discussionmentioning

confidence: 99%

“…It has been reported that the metabolic changes related to triacylglycerol deposition caused by partial lipectomy are much more dramatic in the hypothalamic obese rats, as compared to the changes observed in the standard diet fed rats. As the model of hypothalamic obesity is not related to hyperfagia [18] and can be induced even with animals fed a standard diet, we questioned whether lipectomyzed wistar rats chronically fed a high fat diet, which mimics a behavioral-related type of obesity, could also present altered triacylglycerol deposition. Thus, the aim of this study was to verify in male wistar rats chronically fed a diet enriched with palatable, inexpensive and energy dense ingredients, the effects of partial removal of white fat pads after 7 or 30 days of surgery.…”

Section: Introductionmentioning

confidence: 99%

White adipose tissue re-growth after partial lipectomy in high fat diet induced obese Wistar rats

et al. 2010

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The effects of partial removal of epididymal (EPI) and retroperitoneal (RET) adipose tissues (partial lipectomy) on the triacylglycerol deposition of high fat diet induced obese rats were analyzed, aiming to challenge the hypothesized body fat regulatory system. Male 28-day-old wistar rats received a diet enriched with peanuts, milk chocolate and sweet biscuits during the experimental period. At the 90th day of life, rats were submitted to either lipectomy (L) or sham surgery. After 7 or 30 days, RET, EPI, liver, brown adipose tissue (BAT), blood and carcass were obtained and analyzed. Seven days following surgery, liver lipogenesis rate and EPI relative weight were increased in L. After 30 days, L, RET and EPI presented increased lipogenesis, lipolysis and percentage of small area adipocytes. L rats also presented increased liver malic enzyme activity, BAT lipogenesis, and triacylglycerol and corticosterone serum levels. The partial removal of visceral fat pads affected the metabolism of high fat diet obese rats, which leads to excised tissue re-growth and possibly compensatory growth of non-excised depots at a later time.

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“…8,9 A administração subcutânea de glutamato monossódico (MSG), um aminoácido neuroexcitatório lesivo ao sistema nervoso central, 10 resulta na degeneração aguda do núcleo arqueado do hipotálamo que leva, além da obesidade, à disfunção sexual, parada no crescimento, ao déficit comportamental em roedores 11 e a alterações no controle cardiovascular. 12 Mais ainda, os animais obesos desse modelo experimental desenvolvem maior deposição de tecido adiposo na região central, possivelmente em virtude de hipercortisolismo. 13 As lesões geradas pelo MSG produzem obesidade hipotalâmica por meio de diversas alterações metabólicas, como hiperinsulinemia e prejuízo da termogênese.…”

Section: Introductionunclassified

Efeito da sobreposição de um modelo de obesidade neuroendócrina experimental e hipertensão arterial sobre a pressão arterial, peso corporal e parâmetros metabólicos e renais de ratos

Ferreira¹,

Cesaretti²,

Voltera³

et al. 2011

J. Bras. Nefrol.

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A pharmacological analysis of food intake regulation in rats treated neonatally with monosodium L-glutamate (MSG)

Cited by 36 publications

References 45 publications

Swimming exercise at weaning improves glycemic control and inhibits the onset of monosodium l-glutamate-obesity in mice

Swimming exercise at weaning improves glycemic control and inhibits the onset of monosodium l-glutamate-obesity in mice

White adipose tissue re-growth after partial lipectomy in high fat diet induced obese Wistar rats

Efeito da sobreposição de um modelo de obesidade neuroendócrina experimental e hipertensão arterial sobre a pressão arterial, peso corporal e parâmetros metabólicos e renais de ratos

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