A Pharmacokinetic Profile of Nizatidine in Man

Gastric fluid volume and pH after nizatidine in adults undergoing elective surgery: influence of timing and dose

“…6,22,28 Unlike cimetidine, no interactions with warfarin, 29 lidocaine, 3~ diazepam, 26 chlorodiazepoxide, 3~ lorazepam, 3! metprolol, 32 or theophylline, 3| all of which may be used in the perioperative period, have been observed in humans.…”

“…[8][9][10][11][12] This highly selective H 2 receptor blocking drug is as potent as ranitidine and highly bioavailable (71%) compared with ranitidine (50%), and achieves peak plasma levels within two hours after an oral dose. 6,13 However, data on the use of nizatidine as a premedicant are limited. We conducted a controlled, randomized, and prospective study to assess the effect of nizatidine in controlling gastric fluid pH and volume in adults.…”

Development and validation of a sensitive LC–MS/MS assay for the quantification of nizatidine in human plasma and urine and its application to pharmacokinetic study

“…The range of the urine calibration curve was determined based on the presumed urinary excretion ratio. Approximately 60% of the dosednizatidine was subsequently excreted into urine in an unchanged form and 40% as metabolites [10], therefore, the ULQC of 800 g/mL was set for the urine calibration. The employment of a 1/x 2 weighting factor was found to achieve optimal accuracy and precision.…”

“…Moreover, a rapid and sensitive method applied to routine urine analysis is necessary for drugs excreted primarily through glomerular filtration and active tubular secretion. According to the report by Callaghan et al [10], 90% of nizatidine was excreted by the kidneys as the parent drug and metabolites. In their study, unchanged nizatidine accounted for 65% of recovered substances after oral administration, which strongly suggests that a robust detection of nizatidine in urine is required.…”

Dose‐dependent heart rate reducing effect of nizatidine, a histamine H2‐ receptor antagonist.

“…Heart rate and cardiac output values returned to baseline at about 6 h after the administration of nizatidine. This may be explained by the pharmacokinetic profile of this H2-receptor antagonist, with a plasma half-life of 1 to 3 h after oral administration (Callaghan et al, 1985(Callaghan et al, , 1987.…”