A pharmacodynamic approach to the evaluation of nitrites in the treatment of angina pectoris∗

Synergistic Actions of Nitrite-β-Adrenergic Blocking Agents in the Therapy of Angina Pectoris

“…An entirely different approach to the problem of prophylactic antianginal drugs has been the development by pharmaceutical means of controlled-release preparations of the inherently short-acting nitroglyc erin [38], These preparations have clearly been shown by a number of authors to be readily absorbed into the systemic circulation in man and to exert peripheral and coronary vasodilating effects over a period of as long as 6-8 h [8,20,21,31,32,35,58,66,70,73]. An encouraging preliminary report of a double-blind study by Winsor [71,72] and W insor et al [73] on the clinical effectiveness of such a preparation (Nitrong, oral controlled-release nitroglycerin tablets; Wharton Laboratories, Inc., Div.…”