A phantom study: Should <sup>124</sup>I‐mIBG PET/CT replace <sup>123</sup>I‐mIBG SPECT/CT?

Beijst, Casper; Keizer, Bart de; Lam, Marnix G. E. H.; Janssens, Geert O.; Tytgat, Godelieve A.M.; Jong, Hugo W. A. M. de

doi:10.1002/mp.12202

Cited by 21 publications

(16 citation statements)

References 34 publications

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“…Image quality was assessed using CNR calculated according to Eq. ():

C N R = \frac{C_{S} ‐ C_{B}}{σ_{B}}

where

C_{S}

represents the average number of counts in each sphere,

C_{B}

the average number of counts in the background volumes used to determine the CF, and

σ_{B}

the average standard deviation of the background volumes 15 . The Rose criterion , CNR > 5, was used to classify whether an object is detectable or not 16 .…”

Section: Methodsmentioning

confidence: 99%

¹⁷⁷Lutetium SPECT/CT: Evaluation of collimator, photopeak and scatter correction

Huizing

Sinaasappel

Dekker

et al. 2020

J Applied Clin Med Phys

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Purpose The goal of this study was to find the optimal combination of collimator, photopeak and scatter correction for 177Lutetium (177Lu) SPECT/CT imaging. Methods Three experiments [sphere‐to‐background ratios (SBR) 50:1, 10:1, and 2:1] were performed with the NEMA Image Quality phantom filled with 177Lu‐trichloride. SPECT/CT acquisitions were performed with the medium‐energy low‐penetration (MELP) collimator and 99mTc/Krypton collimator. For each acquisition six reconstructions, all with attenuation correction (AC), were made: the 113‐keV photopeak only, the 208‐keV photopeak only and both photopeaks combined, each with or without scatter correction (SC). Image quality was assessed using contrast‐to‐noise ratios (CNR), quantification accuracy by means of recovery coefficients (RCs) and the spatial resolution using line profiles. Results With SBR 50:1 and 10:1, both collimators met the Rose criterion (CNR > 5), whereas the MELP collimator showed a higher CNR for the 2:1 ratio. The RCmean was higher with the MELP collimator, most explicit after the 208‐keV AC/SC reconstruction for all acquisitions. The line profiles showed a better spatial resolution for the MELP collimator and the 208‐keV AC/SC reconstructions. Conclusion 177Lu SPECT/CT image quality and quantification was most optimal when acquired with the MELP collimator and reconstructed using the 208‐keV photopeak, with AC and SC.

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“…Image quality was assessed using CNR calculated according to Eq. ():

C N R = \frac{C_{S} ‐ C_{B}}{σ_{B}}

where

C_{S}

represents the average number of counts in each sphere,

C_{B}

the average number of counts in the background volumes used to determine the CF, and

σ_{B}

the average standard deviation of the background volumes 15 . The Rose criterion , CNR > 5, was used to classify whether an object is detectable or not 16 .…”

Section: Methodsmentioning

confidence: 99%

¹⁷⁷Lutetium SPECT/CT: Evaluation of collimator, photopeak and scatter correction

Huizing

Sinaasappel

Dekker

et al. 2020

J Applied Clin Med Phys

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“…One approach to improving the quality of nuclear images is therefore to replace SPECT tracers with positron-emitting PET tracers. Examples include the use of diagnostic 124 I-metaiodobenzylguanidine (MIBG) PET instead of 123 I-MIBG SPECT before 131 I-MIBG therapy (51,52) (Fig. 6) or the use of low-abundance internal pair production of 90 Y for 90 Y PET instead of Bremsstrahlung 90 Y SPECT for dosimetry in 90 Y liver radioembolization (Fig.…”

Section: Pet Versus Spectmentioning

confidence: 99%

Technical Advances in Image Guidance of Radionuclide Therapy

Beijst

Kunnen

Lam

et al. 2017

J. Nucl. Med. Technol.

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Internal radiation therapy with radionuclides (i.e., radionuclide therapy) owes its success to the many advantages over other, more conventional, treatment options. One distinct advantage of radionuclide therapies is the potential to use (part of) the emitted radiation for imaging of the radionuclide distribution. The combination of diagnostic and therapeutic properties in a set of matched radiopharmaceuticals (sometimes combined in a single radiopharmaceutical) is often referred to as theranostics and allows accurate diagnostic imaging before therapy. The use of imaging benefits treatment planning, dosimetry, and assessment of treatment response. This paper focuses on a selection of advances in imaging technology relevant for image guidance of radionuclide therapy. This involves developments in nuclear imaging modalities, as well as other anatomic and functional imaging modalities. The quality and quantitative accuracy of images used for guidance of radionuclide therapy is continuously being improved, which in turn may improve the therapeutic outcome and efficiency of radionuclide therapies.

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“…Beijst et al studied the difference in lesion detectability between 131 I-SPECT and 124 I-PET imaging and found that 124 I-PET offers better image quality for similar activity concentrations [8,9].…”

Section: Introductionmentioning

confidence: 99%

Optimizing reconstruction parameters for quantitative 124I-PET in the presence of therapeutic doses of 131I

Fanchon

Beattie

Pentlow

et al. 2021

Preprint

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Purpose To determine the accuracy of quantitative 124I PET imaging in the presence of therapeutic levels of 131I.Material and Methods Multiple PET images were acquired using a NEMA IEC phantom with spheres containing 0.4 MBq/cc of 124I and increasing amount of 131I activity in the phantom background (0 to 3.76 GBq). Acquisitions were performed on a GE Discovery 710 PET/CT scanner. At each 131I activity level two scans were acquired, one with the phantom at the center of the field of view (FOV) and one 11 cm off-center. Images were reconstructed with an ordered subset expectation maximization (OSEM) algorithm using between 1 and 25 iterations of 16 subsets. Results were evaluated visually and by comparing the 124I activity relative to the baseline PET performed in the absence of 131I.Results The presence of 131I within the PET FOV added to the random coincidence rate, to dead-time and to pile-up within the PET detectors. Using our standard clinical reconstruction parameters, the image quality and quantitative accuracy suffered at 131I background activities above 1.4 GBq. However, increasing the number of iterations resulted in dramatic improvements in image quality and quantitative accuracy. Projection space measurements suggest that the dead time corrections implemented on the scanner perform well even at the highest singles count rate tested (52 Mcps).Conclusion This study shows that 124I quantitative PET is feasible in the presence of large amounts of 131I on a GE D710. The high random coincidence fraction slows the reconstruction convergence rate, therefore iterations equivalent to at least 8x16 are recommended.

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A phantom study: Should ¹²⁴I‐mIBG PET/CT replace ¹²³I‐mIBG SPECT/CT?

Cited by 21 publications

References 34 publications

¹⁷⁷Lutetium SPECT/CT: Evaluation of collimator, photopeak and scatter correction

¹⁷⁷Lutetium SPECT/CT: Evaluation of collimator, photopeak and scatter correction

Technical Advances in Image Guidance of Radionuclide Therapy

Optimizing reconstruction parameters for quantitative 124I-PET in the presence of therapeutic doses of 131I

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A phantom study: Should 124I‐mIBG PET/CT replace 123I‐mIBG SPECT/CT?

Cited by 21 publications

References 34 publications

177Lutetium SPECT/CT: Evaluation of collimator, photopeak and scatter correction

177Lutetium SPECT/CT: Evaluation of collimator, photopeak and scatter correction

Technical Advances in Image Guidance of Radionuclide Therapy

Optimizing reconstruction parameters for quantitative 124I-PET in the presence of therapeutic doses of 131I

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A phantom study: Should ¹²⁴I‐mIBG PET/CT replace ¹²³I‐mIBG SPECT/CT?

¹⁷⁷Lutetium SPECT/CT: Evaluation of collimator, photopeak and scatter correction

¹⁷⁷Lutetium SPECT/CT: Evaluation of collimator, photopeak and scatter correction