A pH/Temperature-Sensitive s-IPN Based on Poly(vinyl alcohol), Poly(vinyl methyl ether-alt-maleic acid) and Poly(vinyl methyl ether) Prepared by Autoclaving

García-Verdugo, Karla F.; Ramírez‐Irigoyen, Andya J.; Castillo-Ortega, Mónica; Rodríguez-Félix, Dora Evelia; Quiroz-Castillo, Jesus Manuel; Tánori-Córdova, Judith; Rodríguez-Félix, Francisco; Ledezma‐Pérez, Antonio; Castillo-Castro, T. del

doi:10.1007/s13233-022-0044-6

Cited by 7 publications

(8 citation statements)

References 56 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…IPN hydrogels may be preferred over polymer blends due to their improved mechanical strength, controlled swelling behavior and efficient drug loading capacity [ 259 , 261 ]. One of the most used biopolymers for IPN formation is CTS, as reported by Dragan et al (2020) [ 262 ], although there have been a large number of research papers based on IPN hydrogels synthesized with different synthetic and natural polymers, such as COL [ 263 , 264 , 265 ], GEL [ 266 , 267 , 268 ], alginate [ 267 , 269 , 270 ], polyurethane [ 264 , 265 , 270 ], PVA [ 268 , 271 ], PEG [ 272 , 273 ] and poly (aspartic acid) [ 274 ], among other candidate polymers. In this sense, there is a wide range of possibilities by means of materials and synthesis procedures that can be used for IPNs formation, owing to their outstanding physicochemical properties.…”

Section: Hybrid Hydrogel Compositesmentioning

confidence: 99%

Novel Trends in Hydrogel Development for Biomedical Applications: A Review

et al. 2022

View full text Add to dashboard Cite

Nowadays, there are still numerous challenges for well-known biomedical applications, such as tissue engineering (TE), wound healing and controlled drug delivery, which must be faced and solved. Hydrogels have been proposed as excellent candidates for these applications, as they have promising properties for the mentioned applications, including biocompatibility, biodegradability, great absorption capacity and tunable mechanical properties. However, depending on the material or the manufacturing method, the resulting hydrogel may not be up to the specific task for which it is designed, thus there are different approaches proposed to enhance hydrogel performance for the requirements of the application in question. The main purpose of this review article was to summarize the most recent trends of hydrogel technology, going through the most used polymeric materials and the most popular hydrogel synthesis methods in recent years, including different strategies of enhancing hydrogels’ properties, such as cross-linking and the manufacture of composite hydrogels. In addition, the secondary objective of this review was to briefly discuss other novel applications of hydrogels that have been proposed in the past few years which have drawn a lot of attention.

show abstract

Section: Hybrid Hydrogel Compositesmentioning

confidence: 99%

Novel Trends in Hydrogel Development for Biomedical Applications: A Review

et al. 2022

View full text Add to dashboard Cite

show abstract

“…The H-polymer spectrum exhibits the main bands of neat polymers (Figure a) . The band at 3396 cm –1 , broadened toward lower wavenumbers, is associated with the stretching vibration of hydrogen-bonded OH groups of PVA and COP.…”

Section: Results and Discussionmentioning

confidence: 99%

“…Poly(vinyl alcohol) (PVA) Mw 85,000–124,000, 99% hydrolyzed; poly(vinyl methyl ether- alt -maleic anhydride) (PVME-MA) Mw 216,000; poly(vinyl methyl ether) (PVME) 50 wt % in water; multiwalled carbon nanotubes (MWCNT) (≥98%, Aldrich, OD × ID × L : 10 ± 1 nm × 4.5 ± 0.5 nm × 3–6 μm); sodium dodecyl sulfate (SDS); 5-fluorouracil (5-FU) 99%; and ibuprofen sodium salt ≥98% were purchased from Sigma-Aldrich. The PVME-MA reagent was dissolved in water and thermally treated at 70 °C for 6 h to obtain poly(vinyl methyl ether- alt -maleic acid) (COP) . Functionalized multiwalled carbon nanotubes (MWCNT-f) were obtained by the microwave-assisted treatment of MWCNT with a strong acid mixture, as reported previously by our research group .…”

Section: Methodsmentioning

confidence: 99%

“…The combination of PVA with polymers that contain hydrogen bond donor or acceptor groups has been used to strengthen the physical PVA networks via noncovalent interactions. − Recently, our research group reported the preparation of semi-interpenetrating polymer networks formed by PVA, poly(vinyl methyl ether- alt -maleic acid) (COP in this report), and poly(vinyl methyl ether) (PVME) through an autoclaving process . COP is a water-soluble, biocompatible polymer that has been approved for biotechnology and pharmacology fields. − On the other hand, PVME has been used as a steric stabilizer in several polymer blends due to its dual hydrophilic and hydrophobic nature. − In this sense, the design and preparation of multifunctional composite hydrogels by simple and nontoxic methods are important goals toward the construction of NIR light-responsive platforms for biomedical applications.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Nanocomposite Hydrogels Based on Poly(vinyl alcohol) and Carbon Nanotubes for NIR-Light Triggered Drug Delivery

García Verdugo,

Salazar Salas,

Chan

et al. 2024

ACS Omega

View full text Add to dashboard Cite

Photothermal nanocomposite hydrogels are promising materials for remotely triggering drug delivery by nearinfrared (NIR) radiation stimuli. In this work, a novel hydrogel based on poly(vinyl alcohol), poly(vinyl methyl ether-alt-maleic acid), poly(vinyl methyl ether), and functionalized multiwalled carbon nanotubes (MWCNT-f) was prepared by the freeze/thaw method. A comparative characterization of materials (with and without MWCNT-f) was carried out by infrared spectroscopy, differential scanning calorimetry, scanning electron microscopy, mechanical assays, swelling kinetics measurements, and photothermal analysis under NIR irradiation. Hydrophilic chemotherapeutic 5-fluorouracil (5-FU) and hydrophobic ibuprofen drugs were independently loaded into hydrogels, and the drug release profiles were obtained under passive and NIR-irradiation conditions. The concentration-dependent cytotoxicity of materials was studied in vitro using noncancerous cells and cancer cells. Notable changes in the microstructure and physicochemical properties of hydrogels were observed by adding a low content (0.2 wt %) of MWCNT-f. The cumulative release amounts of 5-FU and ibuprofen from the hydrogel containing MWCNT-f were significantly increased by 21 and 39%, respectively, through the application of short-term NIR irradiation pulses. Appropriate concentrations of the nanocomposite hydrogel loaded with 5-FU produced cytotoxicity in cancer cells without affecting noncancerous cells. The overall properties of the MWCNT-f-containing hydrogel and its photothermal behavior make it an attractive material to promote the release of hydrophilic and hydrophobic drugs, depending on the treatment requirements.

show abstract

“…[26][27][28][29][30] Further control is possible by hybridization with multiple polymers, interpenetrating network (IPN), and nanocomposite formation. [17,31,32] With these changes in mechanics, there is also a concurrent change in permeability. Thus, the ability to control the diffusion of soluble factors also makes hydrogels attractive as drug delivery systems.…”

Section: Limitations Of Current Hydrogel Technology: Mechanical Consi...mentioning

confidence: 99%

Emerging Technology of Nanofiber‐Composite Hydrogels for Biomedical Applications

Choi

Yun

Cha

2023

Macromolecular Bioscience

View full text Add to dashboard Cite

Hydrogels and nanofibers have been firmly established as go‐to materials for various biomedical applications. They have been mostly utilized separately, rarely together, because of their distinctive attributes and shortcomings. However, the potential benefits of integrating nanofibers with hydrogels to synergistically combine their functionalities while attenuating their drawbacks are increasingly recognized. Compared to other nanocomposite materials, incorporating nanofibers into hydrogel has the distinct advantage of emulating the hierarchical structure of natural extracellular environment needed for cell and tissue culture. The most important technological aspect of developing “nanofiber‐composite hydrogel” is generating nanofibers made of various polymers that are crosslinked and short enough to maintain stable dispersion in hydrated environment. In this review, recent research efforts to develop nanofiber‐composite hydrogels are presented, with added emphasis on nanofiber processing techniques. Several notable examples of implementing nanofiber‐composite hydrogels for biomedical applications are also introduced.This article is protected by copyright. All rights reserved

show abstract

A pH/Temperature-Sensitive s-IPN Based on Poly(vinyl alcohol), Poly(vinyl methyl ether-alt-maleic acid) and Poly(vinyl methyl ether) Prepared by Autoclaving

Cited by 7 publications

References 56 publications

Novel Trends in Hydrogel Development for Biomedical Applications: A Review

Novel Trends in Hydrogel Development for Biomedical Applications: A Review

Nanocomposite Hydrogels Based on Poly(vinyl alcohol) and Carbon Nanotubes for NIR-Light Triggered Drug Delivery

Emerging Technology of Nanofiber‐Composite Hydrogels for Biomedical Applications

Contact Info

Product

Resources

About