A pH-sensitive near-infrared fluorescent probe with alkaline pK_a for chronic wound monitoring in diabetic mice

Abstract

An alkaline pH-sensitive near-infrared fluorescent probe can monitor pH changes in the course of chronic wound development in mice.

Synthesis of a New Amino-Furopyridine-Based Compound as a Novel Fluorescent pH Sensor in Aqueous Solution

“…Development of small fluorescent molecules, − especially pH-sensitive fluorescent dyes, has gained substantial attention owing to their promising applications in various fields, including analytical chemistry, , biomedicinal research, − clinical diagnostics, − biology, − and environmental science . They are used as strainers, biomolecular labels, , environmental indicators, etc.…”

Recent Progress in Fluorescent Probes for Diabetes Visualization and Drug Therapy

“…In 2019, Wu and coworkers reported a NIR fluorescent probe (32) for sensitivity examining pH (Figure 27A) [130]. The pH experiments revealed that the fluorescence emission of probe 32 decreased drastically in the region of pH from 7.0 to 10.5.…”

Topical pH Sensing NIR Fluorophores for Intraoperative Imaging and Surgery of Disseminated Ovarian Cancer

“…[ 30 , 31 ] A hallmark of the tumor microenvironment (TME) is the acidic condition created by altered metabolism (a.k.a., the Warburg effect). [ 32 , 33 , 34 ] Typically, non‐cancerous cells display an extracellular pH of around 7.5, while tumor cells show 6.4–7.1. [ 35 ] Since imaging probes generally lack endogenous targeting mechanisms, they have often been combined with a targeting moiety to enhance contrast, such as antibodies which are generally large in molecular weight and show slow clearance.…”