A pH-responsive organic photosensitizer specifically activated by cancer lysosomes

Xue, Fengfeng; Wei, Peng; Ge, Xiaoting; Zhong, Yaping; Cao, Chunyan; Yu, Dao‐Yi; Yi, Tao

doi:10.1016/j.dyepig.2018.04.008

Cited by 39 publications

(29 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…116,117 Most of the accessible activatable BODIPY-based PSs are thereby based on the combination of the conceptual designs for BODIPY-based sensors and BODIPY-based PSs as exemplarily shown in Figure 7 for pH-or viscosity-activatable PSs. 113,114,[118][119][120][121][122]…”

Section: Figurementioning

confidence: 99%

Simple Self-Referenced Luminescent pH Sensors Based on Upconversion Nanocrystals and pH-Sensitive Fluorescent BODIPY Dyes

et al. 2019

View full text Add to dashboard Cite

Optical probes for monitoring, imaging, and sensing of pH are of great interest for the scientific community as pH is a crucial marker for many processes in biotechnology, biology, medical diagnostics, biomedical research, and material corrosion. Thereby, optical pH sensors based on fluorescence have attracted interest in particular as fluorescence offers a high sensitivity down to the single molecule level, can be read out with relatively simple and readily miniaturized instrumentation, and allows online in situ measurements. Also the versatility ranging from molecular and nanosensor formats to planar optodes and fiber-optic sensors, and the non-invasive, non-destructive, and contactless nature of the measurement are application-friendly features. The information content, which is offered by a fluorescence intensity-based sensor, is usually unspecific and limited on the presence or the absence of the chromophore or analyte and can additionally be hampered by fluctuation of the excitation light intensity and changes in fluorophore concentration, e.g., due to photobleaching. Therefore, many fluorescence sensors are utilized in referenced systems, which enable twowavelength ratiometric measurements of the fluorescence intensity by the introduction of an analyte-inert reference with a spectrally distinguishable emission. This work presents the rational design of a versatile, modular, multi-component-based platform for ratiometric optical analyte sensing that can be simply adapted to different formats and measurement geometries. Therefore, readily available analyte-responsive fluorescent boron-dipyrromethene (BODIPY) dyes and near infrared (NIR)-excitable multicolour-Partikelgrößen wurden dafür via Transmissionselektronenmikroskopie (TEM) und Kleinwinkel-Röntgenstreuung (SAXS) bestimmt. Neben der Partikelgröße konnten durch die TEM-Messungen auch Informationen über die Kristallphasen der Nanopartikel erhalten werden. Neben der Erfassung des Partikelwachstums wurde die UCL der UCNPs für die ratiometrische Sensorplattform als Nanolampe und gleichzeitig als Referenzsignal verwendet. Die blaue Upconversion(UC)-Emission der NaYF 4 :Yb 3+ /Tm 3+ UCNPs wurde dabei zur Anregung der pH-sensitiven BODIPY-Farbstoffe verwendet, während die rote UC-Emission als inertes Referenzsignal verwendet wurde. Die Berechnung des Verhältnisses der Emissionsintensitäten der grünen Fluoreszenz des Farbstoffs und der roten UC-Emission des Partikels ermöglicht eine Bestimmung des pH-Werts. Das Potenzial dieser Strategie zur Erfassung des pH-Werts wurde beispielhaft für die Bestimmung der zeitabhängigen Änderungen des pH-Werts einer metabolisierenden Escherichia coli (E. coli)-Suspension gezeigt.

show abstract

Section: Figurementioning

confidence: 99%

Simple Self-Referenced Luminescent pH Sensors Based on Upconversion Nanocrystals and pH-Sensitive Fluorescent BODIPY Dyes

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Intracellular pH is reported to be ~7.2 in normal cells and ≥7.4 in cancer cells [ 102 ]. Additionally, the lysosomes and intracellular compartments of tumor cells are more acidic than those of normal cells, very likely in relation to the presence of H + -ATPases, such that the lysosomal pH value in cancer cells was reported to be in the range low as 3.8–5.0 for cancer cells and in the range 4.5–6.0 for normal cells [ 103 , 104 , 105 ]. These pH differences can be applied for preparing DDSs releasing the drug at the target site, thus reducing the side effects of anticancer drugs and also improving the effectiveness of the chemotherapy ( Figure 4 ).…”

Section: Environment-responsive Ga-functionalized Ddssmentioning

confidence: 99%

Recent Advances in Glycyrrhetinic Acid-Functionalized Biomaterials for Liver Cancer-Targeting Therapy

et al. 2022

View full text Add to dashboard Cite

Liver cancer is one of the most common causes of cancer mortality worldwide. Chemotherapy and radiotherapy are the conventional therapies generally employed in patients with liver tumors. The major issue associated with the administration of chemotherapeutics is their high toxicity and lack of selectivity, leading to systemic toxicity that can be detrimental to the patient’s quality of life. An important approach to the development of original liver-targeted therapeutic products takes advantage of the employment of biologically active ligands able to bind specific receptors on the cytoplasmatic membranes of liver cells. In this perspective, glycyrrhetinic acid (GA), a pentacyclic triterpenoid present in roots and rhizomes of licorice, has been used as a ligand for targeting the liver due to the expression of GA receptors on the sinusoidal surface of mammalian hepatocytes, so it may be employed to modify drug delivery systems (DDSs) and obtain better liver or hepatocyte drug uptake and efficacy. In the current review, we focus on the most recent and interesting research advances in the development of GA-based hybrid compounds and DDSs developed for potential employment as efficacious therapeutic options for the treatment of hepatic cancer.

show abstract

“…With the development of fluorescent bioprobes, researchers became able to visualize the once invisible organelles revealing important and significant insight . Development of the bioprobes has resulted in organelle specific staining agents allowing researchers to study the targeted organelle . The visualization techniques reveal the location and morphology of the organelles, and thus enable the study and monitoring of changes that reveal important biological states or dysfunction .…”

Section: Introductionmentioning

confidence: 99%

Red AIE‐Active Fluorescent Probes with Tunable Organelle‐Specific Targeting

Alam

Leung

et al. 2020

Adv Funct Materials

102

View full text Add to dashboard Cite

Cell staining is a fascinating research area where monitoring and visualizing different cell organelles can be done using fluorescence techniques. However, the design and synthesis of organelle‐targeting fluorophores is still a challenge for several specific organelles. Herein, a platform for synthesizing efficient red‐emitting aggregation‐induced emission luminogens (AIEgens) with donor–acceptor characteristics is reported. The core molecule can be easily functionalized in order to modulate organelle targeting. The three synthesized AIEgens exhibit quantum yields of up to 39.3% and two‐photon absorption cross‐section values of up to 162 GM. The two zwitterionic AIEgens, CDPP‐3SO3 and CDPP‐4SO3, with the sulfonate function group, are successfully utilized for specific one‐photon and two‐photon imaging of the endoplasmic reticulum (ER) in live human cells. Substituting the zwitterionic nature with a singly positive charge group, one‐photon and two‐photon imaging of CDPP‐BzBr shows mitochondrial specificity, indicating the importance of the zwitterionic group for ER‐targeting. Owing to the good in vitro photostability, cell viability, and high efficiency, these red dyes serve as a good potential candidate for specific organelle targeting, as well as illustrate how such a platform can easily aid in the study of structure–property relationships for designing such probes.

show abstract

A pH-responsive organic photosensitizer specifically activated by cancer lysosomes

Cited by 39 publications

References 27 publications

Simple Self-Referenced Luminescent pH Sensors Based on Upconversion Nanocrystals and pH-Sensitive Fluorescent BODIPY Dyes

Simple Self-Referenced Luminescent pH Sensors Based on Upconversion Nanocrystals and pH-Sensitive Fluorescent BODIPY Dyes

Recent Advances in Glycyrrhetinic Acid-Functionalized Biomaterials for Liver Cancer-Targeting Therapy

Red AIE‐Active Fluorescent Probes with Tunable Organelle‐Specific Targeting

Contact Info

Product

Resources

About