A pH-responsive nano-carrier with mesoporous silica nanoparticles cores and poly(acrylic acid) shell-layers: Fabrication, characterization and properties for controlled release of salidroside

Peng, Hailong; Dong, Ruichen; Wang, Shenqi; Zhang, Zhong; Luo, Ming; Bai, Chen; Zhao, Qiang; Li, Jinhua; Chen, Lingxin; Xiong, Hua

doi:10.1016/j.ijpharm.2013.01.071

Cited by 113 publications

(52 citation statements)

References 43 publications

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“…Although MSN could be one of the best candidates for many current bioapplications, especially for DDS, serious disadvantages have been recognized [69,[71][72][73].…”

Section: Research Challenges For Msnmentioning

confidence: 99%

“…Native MSN have proved to be unable to release in a suitable manner, preventing a physiological or therapeutic need to be satisfied in the proper way, increasing also toxicity and diminishing treatment efficiency [44, 73,75]. Precise control over the release kinetics without initial burst upon placement of the nanocarrier in the medium and accurate regulation of the drug release to achieve a stable profile is still required [72,76,77].…”

Section: Burst Release and Controlled Deliverymentioning

confidence: 99%

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Colloidal and spherical mesoporous silica particles: synthesis and new technologies for delivery applications

Beltrán-Osuna

Perilla

2015

J Sol-Gel Sci Technol

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Continuous research in prominent fields such as biotechnology, biomedicine and nanopharmaceutics has brought the development of a widespread class of materials, and studies for mesoporous materials have been exponentially growing lately. The purpose of this review is to provide a useful guide for different materials, methods and configurations that have been reported in the last 5 years for the synthesis of spherical mesoporous silica particles (MSP), in the colloidal size range (1-1000 nm). MSP exhibit several limitations that must be overcome in order to enable their medical and clinical use. Surface modification of these particles will allow getting new promising characteristics of these materials, including better drug release control and biocompatibility improvement. These modified MSP could be potentially used in many biomedical applications, especially for drug delivery systems. Emphasis is made on the pore size, diameter and shape of the final particles since these parameters will establish key characteristics, i.e., drug delivery profile, loading capacity and efficiency. Graphical Abstract Spreading the use of mesoporous silica particles in biomedicine is possible by the improvement of its inner characteristics through surface modification. This may be done by chemical functionalization or by coating with macromolecular layers or brushes, thus creating novel responsive core-shell hybrid composites to be used as carriers for drug delivery applications.

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“…Although MSN could be one of the best candidates for many current bioapplications, especially for DDS, serious disadvantages have been recognized [69,[71][72][73].…”

Section: Research Challenges For Msnmentioning

confidence: 99%

Section: Burst Release and Controlled Deliverymentioning

confidence: 99%

Colloidal and spherical mesoporous silica particles: synthesis and new technologies for delivery applications

Beltrán-Osuna

Perilla

2015

J Sol-Gel Sci Technol

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“…Besides, another promising material, stimuli-responsive polymers (SRPs), also known as environmental responsive polymers or smart polymers, has also attracted widespread interest [15,16]. SRPs are able to respond to specific external stimuli with considerable changes in their physicochemical properties, including molecular chain structure, solubility, surface structure, swelling or dissociation behavior, etc., and various stimuli signals are available such as temperature, pH, magnetism and light [17].…”

Section: Introductionmentioning

confidence: 99%

Thermosensitive molecularly imprinted polymers on porous carriers: Preparation, characterization and properties as novel adsorbents for bisphenol A

Dong

Xiong

et al. 2014

Talanta

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a b s t r a c tThermosensitive molecularly imprinted polymers (T-MIPs) on porous carriers were prepared via the synergy of dual functional monomers of 4-vinylpyridine (VP) and N-isopropylacrylamide (NIPAM), for selective recognition and controlled adsorption and release of bisphenol A (BPA) by the temperature regulation. The porous polymer supporter was synthesized by multistep swelling of polystyrene and then both the NIPAM with temperature responsiveness and the basic monomers of VP were grafted on them in a simple way. The resultant T-MIPs showed high binding capacity, fast kinetics, and the adsorption processes were found to follow Langmuir-Freundlich isotherm and pseudo-second-order kinetic models. The adsorption capacity increased slightly along with the rise of temperature (such as 20 1C) under lower critical solution temperature (LCST, 33 1C) and decreased fast above LCST (such as 50 1C). Subsequently, the T-MIPs were employed as novel adsorbents for selective solid-phase extraction (SPE) of BPA from seawater and yogurt samples. Satisfying recoveries in the range of 94.83-98.47% were obtained with the precision of 3.21% at ambient temperature (20 1C). Through 6 adsorption-desorption cycles, the reusable T-MIPs exhibited a good recoverability with the relative standard error within 9.8%. The smart T-MIPs provided great potentials for selective identification, adsorption/release and removal of BPA by simple stimuli responsive regulation.

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“…21 Figure 1 shows the chemical structures of salidroside and paeonol. Combined delivery of these two compounds is not possible using simple drug solutions or conventional preparations.…”

Section: Introductionmentioning

confidence: 99%

Sequential release of salidroside and paeonol from a nanosphere-hydrogel system inhibits ultraviolet B-induced melanogenesis in guinea pig skin

Peng¹,

Xu²,

Shan³

et al. 2014

IJN

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Melanin is the one of most important pigments for skin color in mammals. Excessive biosynthesis of melanin induces various pigment disorders. Much effort has been made to develop regulators to minimize skin pigmentation abnormalities. However, only a few of them are used, primarily because of safety concerns and low efficiency. In this study, we aimed to construct a novel nanosphere-gel for sequential delivery of salidroside and paeonol, to investigate the synergistic effects of these drugs in anti-melanogenesis, and to decrease their potential for toxicity in high dosage. Nanospheres were prepared and characterized for their particle size, polydispersity index, zeta potential, and morphological properties. The optimized nanospheres were incorporated in carbomer hydrogel with both paeonol and salidroside entrapped to form a dual drug-releasing nanosphere-gel. With this nanosphere-gel, rapid release of salidroside from the hydrogel followed by sustained release of paeonol from the nanosphere was achieved. Using a classical model of the melanogenesis response to ultraviolet exposure, it was shown that the anti-melanogenesis effects of the dual drug-releasing system, in which the doses of the individual drugs were decreased by half, was obviously enhanced when compared with the effects of the single drug preparations. Mechanistically, the burst release of salidroside from the hydrogel may enable prompt suppression of melanocyte proliferation on exposure to ultraviolet B radiation, while the paeonol released in a sustained manner can provide continuous inhibition of tyrosinase activity in melanocytes. Combined delivery of salidroside and paeonol was demonstrated to be a promising strategy for enhancing the therapeutic efficacy of these agents in anti-melanogenesis and reducing their toxicity, so may have great potential in nanomedicine.

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A pH-responsive nano-carrier with mesoporous silica nanoparticles cores and poly(acrylic acid) shell-layers: Fabrication, characterization and properties for controlled release of salidroside

Cited by 113 publications

References 43 publications

Colloidal and spherical mesoporous silica particles: synthesis and new technologies for delivery applications

Colloidal and spherical mesoporous silica particles: synthesis and new technologies for delivery applications

Thermosensitive molecularly imprinted polymers on porous carriers: Preparation, characterization and properties as novel adsorbents for bisphenol A

Sequential release of salidroside and paeonol from a nanosphere-hydrogel system inhibits ultraviolet B-induced melanogenesis in guinea pig skin

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