A pH-responsive controlled release system using layered double hydroxide (LDH)-capped mesoporous silica nanoparticles

Zheng, Qiaoling; Hao, Yanli; Ye, Peirong; Guo, Liangqia; Wu, Hanyin; Guo, Qingquan; Jiang, Jinzhi; Fu, FengFu; Chen, Guonan

doi:10.1039/c3tb00518f

Cited by 52 publications

(31 citation statements)

References 53 publications

(2 reference statements)

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“…Controlled release systems with high performance and responsiveness to different factors such as pH, temperature, and magnetic field have been fabricated with LDHs itself as well as composites comprising mesoporous silica nanoparticles [18], graphene oxide, [19] and magnetic components [20].…”

Section: Introductionmentioning

confidence: 99%

“…Compared with other drug carriers, layered double hydroxides (LDHs), which possess anion-exchange ability, more stable structure, good biocompatibility, controllable particle size and high drug loading [1,2], can be used to encapsulate organic anions such as medicine [3][4][5][6], amino acid [7], vitamins [8,9], pesticides [10] and DNA [11][12][13] to form molecular reservoirs [14,15] in slow and controlled drug release systems [16][17][18]. Controlled release systems with high performance and responsiveness to different factors such as pH, temperature, and magnetic field have been fabricated with LDHs itself as well as composites comprising mesoporous silica nanoparticles [18], graphene oxide, [19] and magnetic components [20].…”

Section: Introductionmentioning

confidence: 99%

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Structure, molecular simulation, and release of a spirin from intercalated Zn–Al-layered double hydroxides

Meng

et al. 2015

Colloids and Surfaces B: Biointerfaces

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Structure, molecular simulation, and release of a spirin from intercalated Zn–Al-layered double hydroxides

Meng

et al. 2015

Colloids and Surfaces B: Biointerfaces

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“…3 The photodynamic principle is based on the stimulation of a nontoxic optical sensing compound (photosensitizer) by nonharmful light to produce reactive oxygen species (ROS) that eliminates the unwanted cells. 8,9 There are some works that show their ability as a carrier in PDT. Therefore, targeting drugs to tumor cells is important in the PDT process.…”

mentioning

confidence: 99%

Photodynamic treatment with anionic nanoclays containing curcumin on human triple‐negative breast cancer cells: Cellular and biochemical studies

Khorsandi

Hosseinzadeh²,

Shahidi

2018

J of Cellular Biochemistry

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Photodynamic treatment is a minimally invasive and clinically approved procedure for eliminating selected malignant cells with activation of a photosensitizer agent at a specific light. Little is known, however, about the phototoxic properties of curcumin, as a natural phenolic compound, against different types of cancers. It is generally accepted that cellular damage occurs during photo treatment. There is a limitation in using of curcumin as a drug due to its low solubility, but nanoparticles such as anionic nanoclays or layered double hydroxide (LDH) could overcome it. The aim of this study was to investigate cellular responses to curcumin‐LDH nanoparticles after photodynamic treatment of MDA‐MB‐231 human breast cancer cells. For this purpose, the MDA‐MB‐231 human breast cancer cell line treated with curcumin‐LDH nanoparticle and then irradiated (photodynamic treatment). After irradiation, lactate dehydrogenase assay, clonogenic cell survival, cell death mechanisms such as autophagy and apoptosis were determined. Cell cycle distribution after photodynamic therapy (PDT) and also intracellular reactive oxygen species (ROS) generation were measured. The result showed that curcumin‐LDH–PDT has a cytotoxic and antiprolifrative effect on MDA‐MB‐231 human breast cancer cells. Curcumin‐LDH–PDT induced autophagy, apoptosis, and G0/G1 cell cycle arrest in human breast cancer cell line. Intracellular ROS increased in MDA‐MB‐231 cancer cell line after treatment with curcumin‐LDH along with irradiation. The results suggest that curcumin‐LDH nanoparticle could be considered as a novel approach in the photodynamic treatment of breast cancer.

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“…Reprinted from Advanced Healthcare Materials spheroidal hematite nanoparticles with a salicylate loaded LDH shell for magnetically controlled drug release that can offer a wide range of applications in biomedicine (Ay et al, 2011). Zheng et al (2013) reported the design of a pH-controlled nano drug delivery system by using a coat of LDH sheets as nano valves to cap the nano pores of drug loaded MSNs. The acid decomposable property of LDH aided in the pH-controlled drug release at acidic pH.…”

Section: Hybrid Nanoconstructsmentioning

confidence: 99%

Layered double hydroxide nanoparticles for biomedical applications: Current status and recent prospects

Kuthati

Kankala

Lee

2015

Applied Clay Science

223

123

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A pH-responsive controlled release system using layered double hydroxide (LDH)-capped mesoporous silica nanoparticles

Cited by 52 publications

References 53 publications

Structure, molecular simulation, and release of a spirin from intercalated Zn–Al-layered double hydroxides

Structure, molecular simulation, and release of a spirin from intercalated Zn–Al-layered double hydroxides

Photodynamic treatment with anionic nanoclays containing curcumin on human triple‐negative breast cancer cells: Cellular and biochemical studies

Layered double hydroxide nanoparticles for biomedical applications: Current status and recent prospects

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