A pH-responsive CaO2@ZIF-67 system endows a scaffold with chemodynamic therapy properties

Qian, Guowen; Wang, Junzhe; Yang, Lei; Zeng, Zhilin; Peng, Shuping; Shuai, Cijun

doi:10.1007/s10853-022-08103-w

Cited by 32 publications

(16 citation statements)

References 52 publications

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“…Obviously, the majority of cells for all samples were viable, indicating their good biocompatibility. 46–49 Moreover, the number of living cells on NH 2 -MXene/PLLA groups excited by rotating MF was higher than that on the rest of the groups, which was attributed to the generated electrical signal promoting the nerve cell growth. 50,51…”

Section: Resultsmentioning

confidence: 99%

An electrical microenvironment constructed based on electromagnetic induction stimulates neural differentiation

Liao

et al. 2023

Mater. Chem. Front.

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Section: Resultsmentioning

confidence: 99%

An electrical microenvironment constructed based on electromagnetic induction stimulates neural differentiation

Liao

et al. 2023

Mater. Chem. Front.

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“…The number and morphologies of cells were imaged using a fluorescence microscope. In the CCK-8 assay, the collected cells were incubated in fresh culture medium with the CCK-8 reagent for 2 h, and then the OD value of the medium was detected by a microplate reader at 450 nm as previously reported. , …”

Section: Methodsmentioning

confidence: 99%

Sustained Endogenous Nitric Oxide Catalytic System Endows Skin Scaffolds with Antibiofilm and Antibacterial Activities

Yang,

Li,

Chen

et al. 2023

ACS Appl. Polym. Mater.

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Infection is the main obstacle to wound repair and usually requires clinical intervention to kill bacteria, while the formed bacterial biofilms protect bacteria against antibacterial treatments. Nitric oxide (NO) therapy is a potential strategy for disrupting biofilms, which encounters a major challenge in the sustainable supply of NO at the wound site. Herein, a nitric oxide catalytic system (Cu@ZIF-8) is constructed by doping Cu 2+ ions on zeolitic imidazolate framework-8 (ZIF-8) via coordination between Cu 2+ ions and dimethylimidazole groups on ZIF-8. Cu@ZIF-8 is then incorporated into poly(p-dioxanone) (PPDO) to prepare a porous skin scaffold, which allows the slow-controlled release of Cu 2+ ions. In this case, the control-released Cu 2+ ions catalyze S-nitrosothiols (RSNOs) enriched at the wound site to continuously supply endogenous NO. NO then reacts with oxygen and free radical superoxide to form reactive nitrogen species to eliminate bacterial biofilms and trigger nitrosative and oxidative stress to kill bacteria. Results showed that the scaffold could continuously release Cu 2+ and catalyze RSNOs to produce NO for more than 28 days, demonstrating the sustainable release ability of NO. The biofilms of Escherichia coli and Staphylococcus aureus cocultured with the scaffold were eliminated by 79.8 and 79.3%, respectively. Moreover, the scaffold showed robust antibacterial activity against E. coli and S. aureus. This study provided an efficient therapy on infection-impaired skin by catalyzing the endogenous donor to produce NO for eliminating biofilms and improving antibacterial activities.

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“…NG and NG-MBG were added into PLLA to prepare NG/PLLA and NG-MBG/PLLA scaffolds using SLS. [29][30][31][32] Meanwhile, the amount of NG was equal in the NG/PLLA and NG-MBG/PLLA scaffolds. Afterward, the NG release behaviors of the two scaffolds were studied using an in vitro immersion experiment.…”

Section: Ng Loading and Releasementioning

confidence: 99%

Direct osteogenesis and immunomodulation dual function via sustained release of naringin from the polymer scaffold

Xiong,

Yuan,

Huang

et al. 2023

J. Mater. Chem. B

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A pH-responsive CaO2@ZIF-67 system endows a scaffold with chemodynamic therapy properties

Cited by 32 publications

References 52 publications

An electrical microenvironment constructed based on electromagnetic induction stimulates neural differentiation

An electrical microenvironment constructed based on electromagnetic induction stimulates neural differentiation

Sustained Endogenous Nitric Oxide Catalytic System Endows Skin Scaffolds with Antibiofilm and Antibacterial Activities

Direct osteogenesis and immunomodulation dual function via sustained release of naringin from the polymer scaffold

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