A PET imaging study of 5-HT1A receptors in cat brain after acute and chronic fluoxetine treatment

Measuring Endogenous 5-HT Release by Emission Tomography: Promises and Pitfalls

“…There are some notable exceptions. First, the strong evidence using immunoelectron microscopy support the hypothesis that 5-HT 1A autoreceptors in the raphe will undergo rapid agonist-induced internalisation, whereas postsynaptic receptors localised in the hippocampus and cortex do not (Aznavour et al, 2006;Riad et al, 2004). This is further supported by the differential expression of G proteins (Mannoury la Cour et al, 2006).…”

Acute and chronic effects of citalopram on 5‐HT1A receptor—Labeling by [18F]MPPF and—Coupling to receptors‐G proteins

“…18 F]MPPF; a 5-HT 1A antagonist) binding demonstrated a decrease in binding sites throughout the DR region (Aznavour et al, 2006;Riad et al, 2001Riad et al, , 2004Sibon et al, 2008;Zimmer et al, 2004). This change was interpreted as evidence of a rapid, yet transitory internalization of 5-HT 1A receptors confirmed by immuno-electron microscopic data and was felt to be responsible for 5-HT 1A autoreceptor desensitization (Aznavour and Zimmer, 2007).…”

Effects of the antidepressant fluoxetine on the subcellular localization of 5-HT 1A receptors and SERT

“…(b) Imaging of 5-HT 1A autoR internalization in the cat and the human brain As the resolution of available microPET instruments was likely to be insufficient to detect a partial decrease in binding potential in such a small anatomical region as the rat DRN [92], a preliminary investigation in animals was carried out in cats using a clinical PET [93]. After demonstrating that the cat DRN could indeed be visualized with [ …”