A PET imaging study of the brain changes of glucose metabolism in patients with temporal lobe epilepsy and depressive disorder

Wen, Jinfeng; Guo, Xinwen; Cao, Xiang-Yi; Liao, Jiwu; Ma, Ping; Hu, Xiangshu; Pan, Jiyang

doi:10.1186/s12880-021-00547-x

Cited by 6 publications

(3 citation statements)

References 25 publications

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“…To the best of our knowledge, this is the first study investigating the metabolic correlates of TTH using [ 18 F]FDG PET within a cohort of BC patients. While it can be speculated that hypometabolism in the right insular areas may represent an [ 18 F]FDG PET trademark of TTH, other possible pre-existing or concomitant conditions, including BC itself, should be considered [ 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 ]. In the first sense, in our sample of BC patients, TTH subjects were more affected by headache days and exhibited PET activity similar to that observed in MiG patients with a higher headache burden.…”

Section: Discussionmentioning

confidence: 99%

Imaging Correlates between Headache and Breast Cancer: An [18F]FDG PET Study

Antunovic,

Artesani,

Viganò

et al. 2023

Cancers

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This study aimed to examine brain metabolic patterns on [18F]Fluorodeoxyglucose ([18F]FDG) positron emission tomography (PET) in breast cancer (BC), comparing patients with tension-type headache (TTH), migraine (MiG), and those without headache. Further association with BC response to neoadjuvant chemotherapy (NAC) was explored. In this prospective study, BC patients eligible for NAC performed total-body [18F]FDG PET/CT with a dedicated brain scan. A voxel-wise analysis (two-sample t-test) and a multiple regression model were used to compare brain metabolic patterns among TTH, MiG, and no-headache patients and to correlate them with clinical covariates. A single-subject analysis compared each patient’s brain uptake before and after NAC with a healthy control group. Primary headache was diagnosed in 39/46 of BC patients (39% TTH and 46% MiG). TTH patients exhibited hypometabolism in specific brain regions before NAC. TTH patients with a pathological complete response (pCR) to NAC showed hypermetabolic brain regions in the anterior medial frontal cortex. The correlation between tumor uptake and brain metabolism varied before and after NAC, suggesting an inverse relationship. Additionally, the single-subject analysis revealed that hypometabolic brain regions were not present after NAC. Primary headache, especially MiG, was associated with a better response to NAC. These findings suggest complex interactions between BC, headache, and hormonal status, warranting further investigation in larger prospective cohorts.

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Section: Discussionmentioning

confidence: 99%

Imaging Correlates between Headache and Breast Cancer: An [18F]FDG PET Study

Antunovic,

Artesani,

Viganò

et al. 2023

Cancers

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“…In the present study, we found that the FC of the right dorsal putamen seed and the bilateral posterior central gyrus was lower in TLE patients than in controls which suggested that these patients may have an impaired putamenposterior central gyrus connection. rs-fMRI studies have shown that patients with TLE exhibit a reduced spontaneous activity in the posterior central gyrus [31] alongside hypometabolism [32] , and reduced blood perfusion [33] . Moreover, studies have proposed that abnormal activity of the posterior central gyrus may affect the sensory processing of the sensorimotor network, leading to sensory disturbances in patients with TLE [34] .…”

Section: Discussionmentioning

confidence: 99%

ML of Striatum rs-fMRI Features Predicts TLE Diagnosis

Jiang¹,

Nie²,

zhang³

et al. 2021

Preprint

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Objective: To determine whether patients with temporal lobe epilepsy (TLE) exhibit aberrant resting-state functional magnetic resonance imaging (rs-fMRI)-functional connectivity and build an individualized TLE prediction model using ML (ML). Methods: Sixty TLE patients and fifty-one controls underwent rs-fMRI scanning. The striatum was divided into 12 striatal seeds. rs-FC was compared between groups to enable TLE classification based on striatal FC using the SPM12, SVM and PRONTO softwares. Bilateral striatal FC values were extracted and significance values were obtained using leave-one-out (LOO) SVM analysis and permutation testing (2,000) for cross-validation.Results: Patients with TLE exhibited a significantly decreased rs-FC between the left inferior ventral striatum and the right posterior central gyrus, left superior frontal gyrus;and between the left dorsal rostral putamen and right superior parietal lobule, right middle frontal gyrus. And between right dorsal caudate And left prefrontal lobe, and right middle temporal gyrus. rs-fMRI analysis a revealed significantly increased FC between the left inferior ventral striatum seed and right anterior cingulate in TLE patients (p<0.05). Right dorsal caudate FC may distinguish individuals with TLE from controls with 79.08% Accuracy, including a 72.77% Sensitivity and 76.44% Specificity, resulting in an AUC of 0.71 (p <0 .01). The areas informing classification included left prefrontal lobe, right middle temporal gyrus, and left superior parietal lobule.Conclusion: Our findings demonstrate aberrant FC in certain brain regions, such as the right dorsal caudate, may play an important role as potential biomarkers of TLE and highlight the utility of ML-based models for clinical decision making.

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“…Previous studies have shown that local glucose metabolism increases in the left dorsal prefrontal cortex and anterior cingulate cortex were observed by 18F-PET/CT in patients with refractory depression after treatment, which is highly correlated with the improvement of depression ( 15 ). In the past, abnormal glucose metabolism in the brain of patients with various malignant tumors has been detected by 18F-PET/CT ( 16 , 17 ), which suggests that there may be tumor-related depression. PET/CT is commonly used in tumor diagnosis, and tumor patients are often accompanied by emotional abnormalities.…”

Section: Introductionmentioning

confidence: 99%

Brain glucose metabolism on [18F]-FDG PET/CT: a dynamic biomarker predicting depression and anxiety in cancer patients

et al. 2023

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ObjectivesTo explore the correlation between the incidence rates of depression and anxiety and cerebral glucose metabolism in cancer patients.MethodsThe experiment subjects consisted of patients with lung cancer, head and neck tumor, stomach cancer, intestinal cancer, breast cancer and healthy individuals. A total of 240 tumor patients and 39 healthy individuals were included. All subjects were evaluated by the Hamilton depression scale (HAMD) and Manifest anxiety scale (MAS), and were examined by whole body Positron Emission Tomography/Computed Tomography (PET/CT) with 18F-fluorodeoxyglucose (FDG). Demographic, baseline clinical characteristics, brain glucose metabolic changes, emotional disorder scores and their relations were statistically analyzed.ResultsThe incidence rates of depression and anxiety in patients with lung cancer were higher than those in patients with other tumors, and Standard uptake values (SUVs) and metabolic volume in bilateral frontal lobe, bilateral temporal lobe, bilateral caudate nucleus, bilateral hippocampus, left cingulate gyrus were lower than those in patients with other tumors. We also found that poor pathological differentiation, and advanced TNM stage independently associated with depression and anxiety risk. SUVs in the bilateral frontal lobe, bilateral temporal lobe, bilateral caudate nucleus, bilateral hippocampus, left cingulate gyrus were negatively correlated with HAMD and MAS scores.ConclusionThis study revealed the correlation between brain glucose metabolism and emotional disorders in cancer patients. The changes in brain glucose metabolism were expected to play a major role in emotional disorders in cancer patients as psychobiological markers. These findings indicated that functional imaging can be applied for psychological assessment of cancer patients as an innovative method.

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A PET imaging study of the brain changes of glucose metabolism in patients with temporal lobe epilepsy and depressive disorder

Cited by 6 publications

References 25 publications

Imaging Correlates between Headache and Breast Cancer: An [18F]FDG PET Study

Imaging Correlates between Headache and Breast Cancer: An [18F]FDG PET Study

ML of Striatum rs-fMRI Features Predicts TLE Diagnosis

Brain glucose metabolism on [18F]-FDG PET/CT: a dynamic biomarker predicting depression and anxiety in cancer patients

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