A perspective review on role of novel NSAID prodrugs in the management of acute inflammation

Peesa, Jaya Preethi; Yalavarthi, Prasanna Raju; Rasheed, Arun; Mandava, Venkata Basaveswara Rao

doi:10.1016/j.joad.2016.08.002

Cited by 43 publications

(26 citation statements)

References 106 publications

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“…Prostaglandins are hormone-like mediators involved in the induction of pain, fever and inflammation [2]. The inhibition of indomethacin to the two COX isozymes with minimal selectivity to COX-2 made the drug have serious complications such as gastric ulcers and renal toxicity upon long-term oral administration [4,5].…”

Section: Introductionmentioning

confidence: 99%

Indomethacin from Anti-Inflammatory to Anticancer Agent

Kassab¹

2019

Medicinal Chemistry

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The chapter "Indomethacin from Anti-inflammatory to Anticancer Agent" covers the recent reports regarding the implication of COX-2/PGE2 in multiple cancer cell proliferation to emphasize the anticancer potential of COX-inhibitors including indomethacin and to reveal that the reduction of PGE2 production interferes with the cancer cell proliferation belongs to multiple cancer cell types. Impressively, indomethacin is involved in antiproliferative and apoptotic actions against cancer cell types via COX-2-independent mechanisms to highlight indomethacin as promising anticancer agent with dual actions to control the cancer cell proliferation. The cardiovascular complications result from diaryl heterocycle sulfonamide/methylsulfone selective COX-2 inhibitors upon reduction in PGE2 and PGI2 production that affects the vascular tone limits the use of Celecoxib as chemopreventive agent against recurrence of colorectal carcinoma cells. Kinetic profile of indomethacin against COX-2 showed obvious difference from that of selective COX-2 inhibitors in which it recovered completely from the enzyme after long time of incubation while COX-2 inhibitors did not recover to impress that this might be implicated in the cardiovascular toxicity of the selective inhibitors. This raised the concern to develop the indomethacin from nonselective COX-to selective COX-2-inhibitors and to assert whether the cardiac complications are from pharmacological class effect or chemical class effect.

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Section: Introductionmentioning

confidence: 99%

Indomethacin from Anti-Inflammatory to Anticancer Agent

Kassab¹

2019

Medicinal Chemistry

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“…The use of these medications is very effective in overcoming pain, fever, and inflammation, but it is often accompanied by side effects on mucosal erosion i.e. that can form ulcers, perforations and bleeding to cause death (1). This happens because NSAIDs have wide enterohepatic circulation.…”

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confidence: 99%

The effect of pisang ambon (Musa paradisiaca L.) stem extract on the regulation of IL-1ß, IL-6 and TNF-α in rats’ enteritis

Kurnijasanti¹,

Candrarisna²

2019

IJVS

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Considering that NSAIDs are widely used in medication for pain, inflammatory, and fever, its side effect, mucosal erosion, needs to be minimized. The purpose of this paper is to study the potential use of Musa paradisiaca L. stem extract in lowering TNFα, IL-1ß and IL-6 proinflammatory cytokines in rats' enteritis. Thirty male wistar strain rats (Rattus Norvegicus) aged 2-3 months were divided into 5 groups with 6 repetitions. The positive and negative control groups were given a solvent of Musa paradisiaca L. stem extract. Groups P1, P2, and P3 were treated with the extract. The groups were treated for 14 days. On the 8th day, all of the rats were administered with Indomethacin as enteritis inducer, except for the rats in the negative control group which were only administered with indomethacin solvent. On the 15th day, the rats were necropsied, and their jejunum were taken in order to make the immunohistochemistry (IHC) preparations. The IHC test results were statistically analyzed using ANOVA and then continued with the Duncan test. The results showed that the granting of Musa paradisiaca L. stem extract has antiinflammatory activity against the inflammated jejunum tissue. The anti-inflammatory activity against the damage of jejunum tissue was indicated by an attenuated expression of IL-1 β, IL-6 and TNF-α proinflammatory cytokines in the jejunum. The increasing dose showed more significant effects.

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“…As neuroinflammation is considered to be involved in the pathophysiology of schizophrenia, anti-in-flammatory treatment strategies along with immune-modulating trials have been conducted. The main mechanism of conventional anti-inflammatory agents such as nonsteroidal anti-inflammatory drugs is the inhibition of the COX pathway of inflammation at the systematic level [112]. Alternatively, biological agents designed to target specific physiological processes could be more useful to modulate neuroinflammation involved in the pathophysiology of schizophrenia.…”

Section: Clinical Evidence For the Therapeutic Effects Of Biological mentioning

confidence: 99%

Anti-inflammatory Strategies for Schizophrenia: A Review of Evidence for Therapeutic Applications and Drug Repurposing

Hong

Bang

2020

Clin Psychopharmacol Neurosci

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Schizophrenia is a debilitating psychiatric disorder with a substantial socioeconomic and humanistic burden. Currently available treatment strategies mostly rely on antipsychotic drugs, which block dopaminergic effects in the mesolimbic pathway of the brain. Although antipsychotic drugs help relieve psychotic symptoms, a definitive cure for schizophrenia has yet to be achieved. Recent advances in neuroinflammation research suggest that proinflammatory processes in the brain could cause alterations in neurobehavioral development and increase vulnerability to schizophrenia. With a growing need for novel strategies in the treatment of schizophrenia, it would be meaningful to review the current evidence supporting the therapeutic potential of anti-inflammatory strategies. This review details the key findings of clinical trials that investigate the efficacy of anti-inflammatory agents as adjuvants to antipsychotic treatment. We further discuss the possibilities of repurposing anti-inflammatory agents and developing novel strategies for the treatment of schizophrenia.

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A perspective review on role of novel NSAID prodrugs in the management of acute inflammation

Cited by 43 publications

References 106 publications

Indomethacin from Anti-Inflammatory to Anticancer Agent

Indomethacin from Anti-Inflammatory to Anticancer Agent

The effect of pisang ambon (Musa paradisiaca L.) stem extract on the regulation of IL-1ß, IL-6 and TNF-α in rats’ enteritis

Anti-inflammatory Strategies for Schizophrenia: A Review of Evidence for Therapeutic Applications and Drug Repurposing

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