A Perspective on the CD47-SIRPA Axis in High-Risk Neuroblastoma
Xao X. Tang,
Hiroyuki Shimada,
Naohiko Ikegaki
Abstract:Neuroblastoma is a pediatric cancer with significant clinical heterogeneity. Despite extensive efforts, it is still difficult to cure children with high-risk neuroblastoma. Immunotherapy is a promising approach to treat children with this devastating disease. We have previously reported that macrophages are important effector cells in high-risk neuroblastoma. In this perspective article, we discuss the potential function of the macrophage inhibitory receptor SIRPA in the homeostasis of tumor-associated macroph… Show more
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