A persisting perception disorder after cannabis use

Ellison‐Wright, Zoë; Sessa, Ben

doi:10.1002/pnp.363

Cited by 6 publications

(3 citation statements)

References 9 publications

(9 reference statements)

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“….may closely resemble the previous hallucinogenic experience, implying that a mechanism related to the original one may be involved" (Lerner et al, 2011). HPPD-a disorder in which individuals continue to experience visual illusions and hallucinations long after the use of hallucinogens and commonly associated with the use of classic psychedelics like LSD-was also suspected as a response to cannabis in a case study of a 15-year-old male (Ellison-Wright and Sessa, 2015). However, the authors of this case study acknowledged confounding factors that could have contributed to this response, including the possibility that the cannabis was contaminated with a psychedelic drug.…”

Section: Perceptual Changesmentioning

confidence: 99%

The psychedelic effects of cannabis: A review of the literature

Wolinsky,

Barrett,

Vandrey

2023

J Psychopharmacol

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Cannabis and classic psychedelics are controlled substances with emerging evidence of efficacy in the treatment of a variety of psychiatric illnesses. Cannabis has largely not been regarded as having psychedelic effects in contemporary literature, despite many examples of historical use along with classic psychedelics to attain altered states of consciousness. Research into the “psychedelic” effects of cannabis, and delta-9-tetrahydrocannabinol (THC) in particular, could prove helpful for assessing potential therapeutic indications and elucidating the mechanism of action of both cannabis and classic psychedelics. This review aggregates and evaluates the literature assessing the capacity of cannabis to yield the perceptual changes, aversiveness, and mystical experiences more typically associated with classic psychedelics such as psilocybin. This review also provides a brief contrast of neuroimaging findings associated with the acute effects of cannabis and psychedelics. The available evidence suggests that high-THC cannabis may be able to elicit psychedelic effects, but that these effects may not have been observed in recent controlled research studies due to the doses, set, and settings commonly used. Research is needed to investigate the effects of high doses of THC in the context utilized in therapeutic studies of psychedelics aimed to occasion psychedelic and/or therapeutic experiences. If cannabis can reliably generate psychedelic experiences under these conditions, high-THC dose cannabis treatments should be explored as potential adjunctive treatments for psychiatric disorders and be considered as an active comparator in clinical trials involving traditional psychedelic medications.

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Section: Perceptual Changesmentioning

confidence: 99%

The psychedelic effects of cannabis: A review of the literature

Wolinsky,

Barrett,

Vandrey

2023

J Psychopharmacol

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“…A vast list of psychoactive substances has been identified and linked with the development of this condition, including Magic Mushrooms (psilocybin) [ 21 ] and muscimol ( Amanita muscaria (L.) Lam.) [ 22 ]; San Pedro cactus and Peyote (mescaline) [ 16 , 23 ]; ketamine [ 24 ]; dextromethorphan [ 25 ]; MDMA and MDA [ 26 ]; and cannabis and synthetic cannabinoids [ 27 , 28 , 29 , 30 , 31 , 32 , 33 ]. This condition has also been associated with the consumption of Ayahuasca, Datura stramonium L., Salvia divinorum Epling & Játiva, and Tabernanthe iboga (L.) Nutt., which contains ibogaine [ 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

Hallucinogen Persisting Perception Disorder: Etiology, Clinical Features, and Therapeutic Perspectives

et al. 2018

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Hallucinogen Persisting Perception Disorder (HPPD) is a rare, and therefore, poorly understood condition linked to hallucinogenic drugs consumption. The prevalence of this disorder is low; the condition is more often diagnosed in individuals with a history of previous psychological issues or substance misuse, but it can arise in anyone, even after a single exposure to triggering drugs. The aims of the present study are to review all the original studies about HPPD in order to evaluate the following: (1) the possible suggested etiologies; (2) the possible hallucinogens involved in HPPD induction; (3) the clinical features of both HPPD I and II; (4) the possible psychiatric comorbidities; and (5) the available and potential therapeutic strategies. We searched PubMed to identify original studies about psychedelics and Hallucinogen Persisting Perception Disorder (HPPD). Our research yielded a total of 45 papers, which have been analyzed and tabled to provide readers with the most updated and comprehensive literature review about the clinical features and treatment options for HPPD.

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“…Although a similar case was reported earlier, the perceptual abnormalities were visual distortions or hallucinations, unlike our patient who had auditory hallucinations. [ 4 ] The reports of cannabis-induced hallucinosis to date are less; hence, further studies are needed to explore such cases.…”

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confidence: 99%