A Peripheral Primitive Neuroectodermal Tumor with Generalized Bone Metastases in a Puppy

Cock, H. E V De; Busch, M. D.M.; Fry, Michael M.; Mehl, Maurice G.; Bollen, Andrew W.; Higgins, Robert

doi:10.1354/vp.41-4-437

Cited by 19 publications

(23 citation statements)

References 10 publications

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“…Tumors involving only the abdominal cavity (not including primary gastric tumors) were found in 4 animals (Nos. [1][2][3][4] and all occurred in perirenal tissue. Tumors involving only the thoracic cavity were identified in 2 animals (Nos.…”

Section: Resultsmentioning

confidence: 99%

“…Body condition was described as thin to emaciated in 11 animals (Nos. 2,4,8,12,14,16,18,19,21,22,24), good in 7 animals (Nos. 3,6,7,9,10,13,17), and was not described in 6 animals.…”

Section: Resultsmentioning

confidence: 99%

“…14, 15), 3 T-cell lymphomas (Nos. 2,15,17), and 2 B-cell lymphomas (Nos. 3,19) formed prominent multinodular periaortic and paravertebral tumor masses within the abdomen, thorax, or both (Fig.…”

Section: Resultsmentioning

confidence: 99%

“…14 There are occasional reports of peripheral primitive neuroblastic and primitive neuroectodermal tumors in animals. 2,3,5,9,[17][18][19]24,25 These tumors are most commonly reported in young dogs 2,5,[17][18][19]24,25 but have also been reported in ruminants. 3,9 Malignant round cell neoplasia diagnosed as lymphoma is the most frequently reported neoplasm in camelids, but most reports are of a single case or a small series of cases.…”

Section: Introductionmentioning

confidence: 99%

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Malignant Round Cell Neoplasia in Llamas and Alpacas

et al. 2009

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Malignant round cell neoplasia was identified in 12 llamas and 12 alpacas aged 0-23 years. Mean age of affected alpacas (3.1 years) was significantly less than that of affected llamas (8.0 years). Tumor cell morphology varied from large and often pleomorphic (11 tumors) to small and often homogeneous (13 tumors). Neoplastic lesions were multicentric in 12 cases. Other sites were gastric (5 cases), intra-abdominal (perirenal; 4 cases), intrathoracic (2 cases), and cervical (1 case). Immunohistochemistry with antibodies to CD79alpha, BLA36, and CD3 identified B-cell lymphoma (12 cases) and T-cell lymphoma (6 cases). Six tumors did not express any lymphoid marker and were further immunostained for neuron-specific enolase (NSE), synaptophysin, S-100, glial fibrillary acidic protein (GFAP), and chromogranin A. All 6 of these tumors were negative for GFAP and chromogranin A but expressed 1 or more of the neural markers NSE, synaptophysin, and S-100 and were classified as primitive malignant round cell tumors (PMRCT). Tumor types could not be distinguished on the basis of animal age, gross pathologic appearance, tumor morphology, or tumor location. All animals with lymphoma and 5 with PMRCT died or were euthanatized. One alpaca with a focal cervical PMRCT lived for at least 20 months after diagnosis. Results of this study indicate that malignant round cell tumors in llamas and alpacas are a heterogeneous group that cannot be distinguished on the basis of signalment, postmortem findings, or routine light microscopic findings. Immunohistochemistry is a valuable diagnostic procedure when evaluating malignant round cell neoplasia in llamas and alpacas.

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Section: Resultsmentioning

confidence: 99%

“…Body condition was described as thin to emaciated in 11 animals (Nos. 2,4,8,12,14,16,18,19,21,22,24), good in 7 animals (Nos. 3,6,7,9,10,13,17), and was not described in 6 animals.…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Malignant Round Cell Neoplasia in Llamas and Alpacas

et al. 2009

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“…PNET can arise in the brain or spinal cord (central PNET) or peripherally in bone or soft tissues (peripheral PNET). Central PNET can be cerebellar (medulloblastoma) or non‐cerebellar . In people, central PNET is reported most frequently in children or young adults, and rarely in older adults .…”

Section: Discussionmentioning

confidence: 99%

Cytologic and immunohistochemical characterization of a primitive neuroectodermal tumor in the brain of a dog

Choi

Labelle²,

Alleman

et al. 2012

Veterinary Clinical Pathol

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A 6-year-old intact female Pointer dog was presented for evaluation of acute onset of ataxia, circling, and head tilt. Neurologic assessment revealed overall decreased postural reaction, left-sided hemiparesis with incoordination, rigidity of fore- and hindlimbs, strabismus of the right eye, and bilateral horizontal nystagmus. Using magnetic resonance imaging, a mass lesion was identified in the cerebrum adjacent to the left side of the cerebellum compressing the brain stem ventrally. The mass was incompletely resected, and during surgery fine-needle aspiration and biopsy of the mass were performed. Cytologically, smears were highly cellular and contained predominantly small to medium-sized discrete round cells with high nuclear to cytoplasmic ratios and round nuclei with rare deep clefts or indentation, smooth chromatin, and indistinct nucleoli. Numerous cytoplasmic fragments were noted in the background. The primary diagnosis was lymphoma; other differential diagnoses included neuroendocrine tumor and poorly differentiated tumor of neural origin. The histologic diagnosis was lymphoma, and the lesion was presumed to be metastatic. On immunohistochemical analysis, the cells expressed neither CD3 nor CD79a. Re-examination of the histologic section revealed disorganized sheets of cells with multifocal palisading and perivascular arrangements of rosette-like structures. An expanded panel of antibodies to vimentin, cytokeratin, glial fibrillary acid protein (GFAP), neuron-specific enolase (NSE), synaptophysin (SYN), S-100, and CD45 was applied to histologic sections. Neoplastic cells were immunoreactive for vimentin, NSE, and S-100. Based on the histologic appearance and immunophenotype of the tumor, a diagnosis of primitive neuroectodermal tumor (PNET) was made. PNET, although rare in dogs, should be considered as a differential diagnosis for round cell tumors in the brain.

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Models for Sarcomas

Hotfilder

Viseur

Vormoor

2007

The Cancer Handbook

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Sarcomas are rare tumours in patients under the age of 20. Because of their characteristic chromosomal translocations Ewing's sarcomas have been a paradigm for understanding the biology of sarcomas. Since the survival rates in Ewing's sarcoma patients with metastasis and relapse are still unsatisfactory, new therapeutic options have to be developed. Model systems based on fibroblast cell lines have helped in understanding the biology of the transforming protein EWS/FLI1. Cell lines established from primary Ewing's sarcoma are now in use to test new therapeutic options. Since these models only poorly reflect the conditions within the patients, xenograft mouse models have recently been developed to study the biology of Ewing's sarcoma in a more relevant in vivo environment. These new model systems will help define novel therapeutic targets and support the preclinical evaluation of new treatments.

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A Peripheral Primitive Neuroectodermal Tumor with Generalized Bone Metastases in a Puppy

Cited by 19 publications

References 10 publications

Malignant Round Cell Neoplasia in Llamas and Alpacas

Malignant Round Cell Neoplasia in Llamas and Alpacas

Cytologic and immunohistochemical characterization of a primitive neuroectodermal tumor in the brain of a dog

Models for Sarcomas

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