A Perfluorochemical Prevents Ischemia–Reperfusion Injury of Muscle

Yabe, Yuichiro; Ishiguro, Naoki; Shimizu, Takuya; Kawasaki, Shouji; Sasaki, Yasuo; Iwata, Hiroji

doi:10.1006/jsre.1996.0311

Cited by 6 publications

(3 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Improved preservation of isolated rat brains, ,, rat heart, canine heart, rabbit kidneys, rat, swine and canine livers, − pig lungs, rabbit heart and lung, and rabbit limbs has been achieved using Fluosol-43 or perfusion media containing this emulsion. The same emulsion was superior to hypothermia in inhibiting free-radical generation and preventing ischemia-reperfusion injury of skeletal muscle in rabbits . Reduced thromboxane release and skeletal muscle reperfusion injury were seen with Fluosol in dogs. , Increased synthesis of the high-energy phosphate phosphocreatine was seen during cold reperfusion of ischemic isolated pig hearts after cardioplegic arrest .…”

Section: Further Potential Indications and Uses Of Fluorocarbon Emuls...mentioning

confidence: 91%

“…The same emulsion was superior to hypothermia in inhibiting free-radical generation and preventing ischemia-reperfusion injury of skeletal muscle in rabbits. 1830 Reduced thromboxane release and skeletal muscle reperfusion injury were seen with Fluosol in dogs. 1831,1832 Increased synthesis of the high-energy phosphate phosphocreatine was seen during cold reperfusion of ischemic isolated pig hearts after cardioplegic arrest.…”

Section: Further Potential Indications and Uses Of Fluorocarbon Emuls...mentioning

confidence: 98%

See 1 more Smart Citation

Oxygen Carriers (“Blood Substitutes”)Raison d'Etre, Chemistry, and Some PhysiologyBlut ist ein ganz besondrer Saft

2001

View full text Add to dashboard Cite

Pharmaceutical Corporation in San Diego; however, the opinion expressed here are solely his and not necessarily those of the Corporation. Jean G. Riess received his chemical engineer and doctorat-e `s-sciences degrees (the latter with Professor Guy Ourisson in 1963) from the University of Strasbourg. He then spent two years with John Van Wazer at Monsanto in Saint-Louis, MO, learning some phosphorus and transitionmetal chemistry. In 1968 he became Professor at the University of Nice, France, where he founded, directed, and eventually became honorary director of the Unite ´de Chimie Mole ´culaire (associated with the Centre National de la Recherche Scientifique). His research successively involved phosphorus chemistry, transition-metal chemistry, organometallics, and eventually perfluorochemicals. His present interests are in fluorocarbons, fluorinated amphiphiles, and their colloid chemistry, including fluorocarbon emulsions for in vivo O 2 delivery, fluorinated self-assemblies, and drug delivery systems. Professor Riess has published about 360 papers and holds ca. 25 patents. He has served on numerous councils and committees and has chaired or co-chaired international conferences on phosphorus chemistry and blood substitutes. He has won awards from the French Academy of Sciences, French Chemical Society, Alexander von Humboldt Stifftung, City of Nice and Controlled Release Society, as well as Alliance's first Distinguished Contribution Award. He holds an honorary Research Associate position at the University of California at San Diego and sits on the Board of Directors of Alliance Pharmaceutical Corp.

show abstract

Section: Further Potential Indications and Uses Of Fluorocarbon Emuls...mentioning

confidence: 91%

Section: Further Potential Indications and Uses Of Fluorocarbon Emuls...mentioning

confidence: 98%

Oxygen Carriers (“Blood Substitutes”)Raison d'Etre, Chemistry, and Some PhysiologyBlut ist ein ganz besondrer Saft

2001

View full text Add to dashboard Cite

show abstract

“…There is also a plethora of literature demonstrating the blockade of reactive oxygen species in skeletal muscle I/R injury by using agents such as glutamine, 9 allopurinol, 10 oxygenated perfluorochemical, 11 and alpha1-acid-glycoprotein. 12 Hypothermic conditions have been studied and found to have a protective effect on skeletal muscle function after many types of tissue injury. [13][14][15] The protective effects of cooling soft tissues can be traced back thousands of years in medical records.…”

Section: Introductionmentioning

confidence: 99%