A peptide inhibitor of macrophage migration in atherosclerosis purified from the leech Whitmania pigra

Hu, Bo; Xu, Lixu; Liu, Ying; Bai, Xu; Xing, Maochen; Cao, Qi; Liang, Hao; Song, Shuliang; Ji, Aiguo

doi:10.1016/j.jep.2020.112723

Cited by 11 publications

(5 citation statements)

References 29 publications

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“…Therefore, Hiesinger and colleagues developed a minimized peptide analog of SDF-1α and demonstrated improved ventricular function in a rat model of MI [ 224 ]. In an interesting example, a purified leech peptide was able to inhibit MF migration through mechanisms involving JNK and p38 MAPK pathways [ 225 ].…”

Section: Therapeutic Strategiesmentioning

confidence: 99%

Control of the post-infarct immune microenvironment through biotherapeutic and biomaterial-based approaches

Soni

D'Elia

Rodell

2023

Drug Deliv. and Transl. Res.

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Ischemic heart failure (IHF) is a leading cause of morbidity and mortality worldwide, for which heart transplantation remains the only definitive treatment. IHF manifests from myocardial infarction (MI) that initiates tissue remodeling processes, mediated by mechanical changes in the tissue (loss of contractility, softening of the myocardium) that are interdependent with cellular mechanisms (cardiomyocyte death, inflammatory response). The early remodeling phase is characterized by robust inflammation that is necessary for tissue debridement and the initiation of repair processes. While later transition toward an immunoregenerative function is desirable, functional reorientation from an inflammatory to reparatory environment is often lacking, trapping the heart in a chronically inflamed state that perpetuates cardiomyocyte death, ventricular dilatation, excess fibrosis, and progressive IHF. Therapies can redirect the immune microenvironment, including biotherapeutic and biomaterial-based approaches. In this review, we outline these existing approaches, with a particular focus on the immunomodulatory effects of therapeutics (small molecule drugs, biomolecules, and cell or cell-derived products). Cardioprotective strategies, often focusing on immunosuppression, have shown promise in pre-clinical and clinical trials. However, immunoregenerative therapies are emerging that often benefit from exacerbating early inflammation. Biomaterials can be used to enhance these therapies as a result of their intrinsic immunomodulatory properties, parallel mechanisms of action (e.g., mechanical restraint), or by enabling cell or tissue-targeted delivery. We further discuss translatability and the continued progress of technologies and procedures that contribute to the bench-to-bedside development of these critically needed treatments. Graphical Abstract

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Section: Therapeutic Strategiesmentioning

confidence: 99%

Control of the post-infarct immune microenvironment through biotherapeutic and biomaterial-based approaches

Soni

D'Elia

Rodell

2023

Drug Deliv. and Transl. Res.

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“…Surprisingly, the separation of responsible peptides from egg white hydrolysates [ 20 ] and antioxidant peptides from feather hydrolysates [ 21 ] was optimized by cation exchange chromatography and reverse-phase chromatography. Furthermore, it was reported that purified hirudin peptides were obtained from leeches ( Hirudo ) by strong base anion-exchange column chromatography and G10 gel column chromatography [ 22 ].…”

Section: Extraction Of Peptidesmentioning

confidence: 99%

Review on Extraction, Modification, and Synthesis of Natural Peptides and Their Beneficial Effects on Skin

Tsopmejio

Wang

et al. 2023

Molecules

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Peptides, functional nutrients with a size between those of large proteins and small amino acids, are easily absorbed by the human body. Therefore, they are seeing increasing use in clinical medicine and have revealed immunomodulatory and anti-inflammatory properties which could make them effective in healing skin wounds. This review sorted and summarized the relevant literature about peptides during the past decade. Recent works on the extraction, modification and synthesis of peptides were reviewed. Importantly, the unique beneficial effects of peptides on the skin were extensively explored, providing ideas for the development and innovation of peptides and laying a knowledge foundation for the clinical application of peptides.

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“…Whitmania pigra Whitman (abbreviated as W. pigra ) is a species of freshwater leech in the family of Haemopidae, which belongs to the class Hirudinea. As a protozoan species of medicinal leech specified in the Chinese Pharmacopoeia, the dried whole body of the leech W. pigra possesses many therapeutic properties for the treatment of the hematencephalon and other thrombosis-related diseases (Dong et al 2016), such as hypertension (Srivastava and Sharma 2010), cerebral infarction (Li et al 2021), ischemic stroke (Xu et al 2016) and atherosclerosis (Hu et al 2020). More than 100 kinds of Chinese patented preparations, containing single leeches or its compatibility form with other herbs, were officially approved to the medical market.…”

Section: Introductionmentioning

confidence: 99%

Genome and transcriptome of freshwater leech Whitmania pigra reveal key genes related to morphogenesis, signal pathways and neurogenesis during embryonic development

Liu

et al. 2022

Preprint

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Whitmania pigra Whitman (phylum Annelida) is a widely distributed freshwater leech in East Asia, with an annual consumption of nearly 1,000 tons dry bodies for curing blood stasis syndrome. W. Pigra has be seen as a representative model organism of neurodevelopmental studies. Here, we sequenced a Chinese individual by sin-gle-molecule real-time (SMRT) long-read sequencing, and generated a de novo as-sembly of 178.87 Mb with contig N50 2.0 Mb. In addition, we obtained a total of 239.64 Gb transcriptome data of eight representative developmental phases of embryos (from blastocyst stage to maturity). Totally, 21482 genes were annotated, among these, 3114 genes were differentially expressed with phase-specific expression pattern, and mainly in the middle and late development (G, H, I, J phase). Using a comprehensive transcriptome dataset, we demonstrated that 57, 49 and 77 DEGs were respectively related to morphogenesis, signal pathways and neurogenesis. 49 DEGs related to signal pathways included 30 wnt genes, 14 notch genes, and 5 hedgehog genes. In par-ticular, we found a cluster consisting of 7 genes related to signal pathways as well as synapses, which were essential for regulating embryonic development. To some ex-tent, our results are helpful to reveal the whole picture of development mechanism from the perspective of transcriptome and also provide new clues for organogenesis and neurodevelopmental studies of Annelida species.

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A peptide inhibitor of macrophage migration in atherosclerosis purified from the leech Whitmania pigra

Cited by 11 publications

References 29 publications

Control of the post-infarct immune microenvironment through biotherapeutic and biomaterial-based approaches

Control of the post-infarct immune microenvironment through biotherapeutic and biomaterial-based approaches

Review on Extraction, Modification, and Synthesis of Natural Peptides and Their Beneficial Effects on Skin

Genome and transcriptome of freshwater leech Whitmania pigra reveal key genes related to morphogenesis, signal pathways and neurogenesis during embryonic development

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