A Pentaerythritol-Based Molecular Scaffold for Solid-Phase Combinatorial Chemistry

Abstract

A convergent synthesis has been developed for the preparation of solid-phase bound construct 1, consisting of an orthogonally protected trifunctional core structure that is attached to TentaGel via a photocleavable linker. [structure: see text]

Highly Interpenetrated Supramolecular Networks Supported by N⋅⋅⋅I Halogen Bonding

“…Only a small number of interpenetrated networks based on XB have hitherto been reported. [16,18] The results described in this paper clearly demonstrate that XB coupled with the use of diiodoperfluoroalkanes offers a reliable means of constructing complex interpenetrated structures by design.…”

“…[13] Recently, it has been used to modulate metal chelation processes, [14] to tune the biological activity of multicomponent systems, [15] and to generate receptor-like libraries. [16] Tetradentate tectons [17] with a rigid tetrahedral core have been frequently employed in Scheme 1. Modules involved in the self-assembly processes.…”

Design and automated generation of artificial estrogen receptor as potential endocrine disruptor chemical binders

“…18,19 In first instance, the photolabile linker was immobilized on aminomethyl TentaGelÔ resin (3) to generate compound 4. Upon Fmoc deprotection, Fmoc-Lys(ivDde)OH was introduced and after Fmoc removal, dipodal steroid scaffold 1 was coupled (5).…”

Pentaerythritol tetrakis(4-iodo-2,3,5,6-tetrafluorophenyl) ether: a tecton for the self-assembly of double strand 1D infinite chains

“…Recently, it has been used to modulate metal chelation processes [23], to tune the biological activity of multicomponent systems [24], to generate receptor-like libraries [25], but it received only occasional attention in supramolecular chemistry [21,26]. We focussed our interest on the synthesis and selfassembly of its tetrakis(4-iodotetrafluorophenyl)ether 1.…”