A pediatric case of tick‐bite–Induced meat allergy and recall urticaria

Saleem, May; Nilsson, Caroline

doi:10.1002/ccr3.4773

Cited by 4 publications

(3 citation statements)

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“…Some may also help with vomiting and nausea. Jackson et al 101 Kaplan and Carson 102 Khoury et al 103 Brzozowska et al 104 Anemüller et al 105 Corticosteroid Prednisone and methylprednisolone Used via oral or intravenous for more severe cases of allergic reaction (controls urticaria, angioedema and pruritis) Ghahramani and Temprano 106 Wen et al 107 Mast cell stabilizer Oral cromolyn solution Reduces persistent gastrointestinal symptoms when avoidance diet is insufficient Commins 42 Antiemetic Domperidone and metoclopramide Reduces vomiting and nausea Zhang et al 108 Saleem and Nilsson 109 Antispasmodic Dicycloverine and hyoscine Helps controlling abdominal pain Guillier et al 110 Brzozowska et al 104 Brenner and Lacy 111 Antidiarrheal Loperamide Used to stop or slow diarrhea (anti-motility drug) Kaplan and Carson 102 Bircher et al 112 Laxative Sennosides and bisacodyl Treat constipation by stimulating bowel movement Emmanuel et al 113 Saleem and Nilsson 109 …”

Section: Treatment/management Methodsmentioning

confidence: 99%

Current and Future Strategies for the Diagnosis and Treatment of the Alpha-Gal Syndrome (AGS)

Vaz-Rodrigues¹,

Mazuecos²,

Fuente³

2022

JAA

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The α-Gal syndrome (AGS) is a pathognomonic immunoglobulin E (IgE)-mediated delayed anaphylaxis in foods containing the oligosaccharide galactose-α-1,3-galactose (α-Gal) such as mammalian meat or dairy products. Clinical presentation of AGS can also comprise immediate hypersensitivity due to anticancer therapy, gelatin-containing vaccines or mammalian serum-based antivenom. The IgE initial sensitization is caused by hard-bodied tick bites and symptomatic individuals typically develop delayed pruritus, urticaria, angioedema, anaphylaxis, malaise or gut-related symptoms. Due to inapparent presentation, delayed reactions and a wide variety of patients´ clinical history, the AGS diagnosis and treatment remain challenging. This review covers not only current diagnostic methods used for AGS such as the skin prick test (SPT), the oral food challenge (OFC), anti-α-Gal IgE levels measurement and the basophil activation test (BAT), but also potentially relevant next-generation diagnostic tools like the mast cell activation test (MAT), the histamine-release (HR) assay, omics technologies and model-based reasoning (MBR). Moreover, it focuses on the therapeutical medical and non-medical methods available and current research methods that are being applied in order to elucidate the molecular, physiological and immune mechanisms underlying this allergic disorder. Lastly, future treatment and preventive tools are also discussed, being of utmost importance for the identification of tick salivary molecules, with or without α-Gal modifications, that trigger IgE sensitivity as they could be the key for further vaccine development. Bearing in mind climate change, the tick-host paradigm will shift towards an increasing number of AGS cases in new regions worldwide, which will pose new challenges for clinicians in the future.

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Section: Treatment/management Methodsmentioning

confidence: 99%

Current and Future Strategies for the Diagnosis and Treatment of the Alpha-Gal Syndrome (AGS)

Vaz-Rodrigues¹,

Mazuecos²,

Fuente³

2022

JAA

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show abstract

“… 2 , 3 Further, 2 recent case reports of AGS described urticaria at the site of a previous tick bite, which was labeled as recall urticaria. 4 , 5 In particular, recall urticaria has been described in case reports in relation to allergen-specific immunotherapy with a local reaction at the site of previous allergen injections after, for example, administration of a new allergen 6 or environmental exposure to the allergen, 7 drugs, 8 or food. 9 In this case, we have more than 10 years of repeated measurements of levels of IgE to alpha-gal, showing the first longitudinal data on how IgE level changes over the course of a decade.…”

mentioning

confidence: 99%

“…10 Further, this case underlines the phenomenon of recall urticaria, which may be a useful clinical sign in the diagnosis of AGS. 4 , 5 Future research should evaluate the proportion and clinical relevance of AGS cases with symptoms related to tick bites and potential recall urticaria.…”

mentioning

confidence: 99%