A pearl study analysis of national neonatal, early neonatal, late neonatal, and corrected Neonatal Mortality Rates in the state of Qatar during 2011: A comparison with World Health Statistics 2011 and Qatar′s historic data over a period of 36 years (1975-2011)

Rahman, Sajjad Ur; Rifai, Hilal Al; Ansari, Walid El; Nimeri, Nuha; Tinay, Sarrah El; Salameh, Khalil; Abbas, Tariq; Jarir, Rawia A; Said, N. El; Taha, Samer

doi:10.4103/2249-4847.105990

Cited by 12 publications

(11 citation statements)

References 15 publications

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“…This population-based study was performed using data retrieved from the PEARL-Peristat Study (Perinatal Neonatal Registry), based on predesigned hospital data pertaining to mothers and newborns [ 47 ]. This database is large enough that the sample size is representative of births in Qatar [ 47 ]. Additionally, since the concept of ETB is a relatively new one, this study is one of only a few studies to examine the risk factors and outcomes associated with ETB.…”

Section: Discussionmentioning

confidence: 99%

Incidence, Risk Factors, and Outcomes of Preterm and Early Term Births: A Population-Based Register Study

Younes

Samara

Al-Jurf

et al. 2021

IJERPH

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Preterm birth (PTB) and early term birth (ETB) are associated with high risks of perinatal mortality and morbidity. While extreme to very PTBs have been extensively studied, studies on infants born at later stages of pregnancy, particularly late PTBs and ETBs, are lacking. In this study, we aimed to assess the incidence, risk factors, and feto-maternal outcomes of PTB and ETB births in Qatar. We examined 15,865 singleton live births using 12-month retrospective registry data from the PEARL-Peristat Study. PTB and ETB incidence rates were 8.8% and 33.7%, respectively. PTB and ETB in-hospital mortality rates were 16.9% and 0.2%, respectively. Advanced maternal age, pre-gestational diabetes mellitus (PGDM), assisted pregnancies, and preterm history independently predicted both PTB and ETB, whereas chromosomal and congenital abnormalities were found to be independent predictors of PTB but not ETB. All groups of PTB and ETB were significantly associated with low birth weight (LBW), large for gestational age (LGA) births, caesarean delivery, and neonatal intensive care unit (NICU)/or death of neonate in labor room (LR)/operation theatre (OT). On the other hand, all or some groups of PTB were significantly associated with small for gestational age (SGA) births, Apgar <7 at 1 and 5 minutes and in-hospital mortality. The findings of this study may serve as a basis for taking better clinical decisions with accurate assessment of risk factors, complications, and predictions of PTB and ETB.

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Section: Discussionmentioning

confidence: 99%

Incidence, Risk Factors, and Outcomes of Preterm and Early Term Births: A Population-Based Register Study

Younes

Samara

Al-Jurf

et al. 2021

IJERPH

Self Cite

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“…Prominent examples are: gestational hypertension (defined as hypertension developed after 20 weeks of pregnancy) [ 3 ], gestational diabetes mellitus (GDM; defined as glucose intolerance that is first detected during pregnancy) [ 4 ], mental health disorders (defined as increased risk of depression and anxiety during pregnancy) [ 5 ], stillbirth (baby born with no signs of life at or after 28 weeks of gestation) [ 6 ], preterm birth (PTB; defined as delivery before the end of 37 weeks of gestation) [ 7 ], preeclampsia (defined as gestational hypertension, proteinuria and hyperuricemia) [ 8 ] and low birth weight (defined when the weight at birth is less than 2500 g) [ 9 ]. The emerging evidence indicates that these pregnancy complications influence the growth and development of the fetus during pregnancy and increase their susceptibility to multiple diseases later in the life [ 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Omouma: a prospective mother and child cohort aiming to identify early biomarkers of pregnancy complications in women living in Qatar

Kumar

Saadaoui

Elhag

et al. 2021

BMC Pregnancy Childbirth

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Background Pregnancy is governed by multiple molecular and cellular processes, which might influence pregnancy health and outcomes. Failure to predict and understand the cause of pregnancy complications, adverse pregnancy outcomes, infant’s morbidity and mortality, have limited effective interventions. Integrative multi-omics technologies provide an unbiased platform to explore the complex molecular interactions with an unprecedented depth. The objective of the present protocol is to build a longitudinal mother-baby cohort and use multi-omics technologies to help identify predictive biomarkers of adverse pregnancy outcomes, early life determinants and their effect on child health. Methods/design : One thousand pregnant women with a viable pregnancy in the first trimester (6–14 weeks of gestation) will be recruited from Sidra Medicine hospital. All the study participants will be monitored every trimester, at delivery, and one-year post-partum. Serial high-frequency sampling, including blood, stool, urine, saliva, skin, and vaginal swabs (mother only) from the pregnant women and their babies, will be collected. Maternal and neonatal health, including mental health and perinatal growth, will be recorded using a combination of questionnaires, interviews, and medical records. Downstream sample processing including microbial profiling, vaginal immune response, blood transcriptomics, epigenomics, and metabolomics will be performed. Discussion It is expected that the present study will provide valuable insights into predicting pregnancy complications and neonatal health outcomes. Those include whether specific microbial and/or epigenomics signatures, immune profiles are associated with a healthy pregnancy and/or complicated pregnancy and poor neonatal health outcome. Moreover, this non-interventional cohort will also serve as a baseline dataset to understand how familial, socioeconomic, environmental and lifestyle factors interact with genetic determinants to influence health outcomes later in life. These findings will hold promise for the diagnosis and precision-medicine interventions.

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“…All pregnant women admitted in four HMG hospitals and all newborn babies (aged 0-27 days, including twins and multiples), admitted in four HMG NICUs were included in the study. For preterm babies, the Perinatal Neonatal Outcomes Research Study (PEARL Study) criteria of neonatal age adjusted for prematurity were used [4]. Term babies more than 28 days PMA (postmenstrual age) were excluded.…”

Section: Introductionmentioning

confidence: 99%

Neonatal Mortality in a Tertiary Care Private Set Up in Saudi Arabia

Rahman¹,

Abdulghani²,

Faleh³

et al. 2019

DSAHMJ

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A pearl study analysis of national neonatal, early neonatal, late neonatal, and corrected Neonatal Mortality Rates in the state of Qatar during 2011: A comparison with World Health Statistics 2011 and Qatar′s historic data over a period of 36 years (1975-2011)

Cited by 12 publications

References 15 publications

Incidence, Risk Factors, and Outcomes of Preterm and Early Term Births: A Population-Based Register Study

Incidence, Risk Factors, and Outcomes of Preterm and Early Term Births: A Population-Based Register Study

Omouma: a prospective mother and child cohort aiming to identify early biomarkers of pregnancy complications in women living in Qatar

Neonatal Mortality in a Tertiary Care Private Set Up in Saudi Arabia

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