A PCSK9 inhibitor induces a transient decrease in the neutrophil-lymphocyte ratio and monocyte-lymphocyte ratio in homozygous familial hypercholesterolemia patients

Li, Fangyuan; Ye, Pucong; Hao, Yu; Du, Juan; Zhang, Hang; Wang, Zengtao; Wang, Xumin; Zeng, Hui; Ma, Yaluan; Lin, Jie

doi:10.1016/j.athplu.2022.05.002

Cited by 2 publications

(1 citation statement)

References 57 publications

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“…In addition, studies have shown that MPV increases in diseases such as DM, acute coronary syndrome, stroke, preeclampsia, and hypercholesterolemia. [23][24][25][26] In a retrospective study of 1876 subjects, the relationship between MPV and plasma fasting glucose levels in the general population was investigated, and MPV was found to be higher in prediabetic patients than in normoglycemic subjects. Moreover, MPV and fasting glucose levels were found to be higher in patients with higher glucose levels than those with low glucose levels, not only in prediabetics but also among patients with normal fasting blood glucose.…”

Section: Discussionmentioning

confidence: 99%

Isolated first hour hyperglycemia in oral glucose tolerance test is associated with insulin resistance

Erdin,

Akgüneş,

Erdin

et al. 2024

ICJIM

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Aims: To investigate metabolic and hemogram derived inflammatory markers in patients with isolated hyperglycemia on 1st hour of oral glucose tolerance test. Methods: The subjects undergone 75 g OGTT for any reason were enrolled to the present retrospective cross sectional study. Plasma glucose, insulin and hemogram derived inflammatory markers, including mean platelet volume (MPV), neutrophil to lymphocyte ratio (NLR), and platelet to lymphocyte ratio (PLR) of the subjects in isolated hyperglycemia group compared to those in healthy controls. Results: Mean PLR of the isolated hyperglycemia and control groups were 106.4±28.8% and 121.4±38%, respectively (p=0.043). Mean HOMA–IR values of patients and controls were 4.09±2.84 and 3.02±2.2, respectively (p=0.027). Plasma glucose at 1st hour was significantly correlated with fasting insulin (r=0.286; p=0.018) and HOMA-IR (r=0.32; p=0.007). Conclusion: We think that isolated 1st hour hyperglycemia in OGTT should not be classified as normal since it is associated with increased fasting insulin and HOMA-IR levels. However, studies with larger cohort are needed to confirm our results

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Section: Discussionmentioning

confidence: 99%