A patient with sarcoidosis and antiphospholipid syndrome

Correlation between Potential Risk Factors and Pulmonary Embolism in Sarcoidosis Patients Timely Treated

“…However, the underlying cause of the association between sarcoidosis and PE remains speculative [ 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 ]. Some authors have hypothesized a role for medication (e.g., corticosteroid and immunosuppressive drugs) [ 8 , 24 , 25 , 26 ].…”

“…Few studies have reported on antiphospholipid syndrome and their findings differed with respect to the presence of antiphospholipid antibodies (38% vs. 2–5%) in sarcoidosis patients [ 1 , 2 , 3 , 8 , 13 , 31 , 32 , 33 ]. It has been reported in the literature that the presence of antiphospholipid antibodies in sarcoidosis patients is correlated with a poor prognosis [ 8 , 13 , 31 , 32 , 33 ], and some authors state that these antibodies are disease markers with a prolonged course and are associated with extrathoracic involvement and persistence of radiographic changes [ 30 , 31 , 32 , 33 , 34 ]. It is known that antiphospholipid antibodies are risk factors for venous thromboembolism and their positivity predisposes to the development of thrombotic complications, even if this positivity does not always determine clinical manifestations.…”

“…It is known that antiphospholipid antibodies are risk factors for venous thromboembolism and their positivity predisposes to the development of thrombotic complications, even if this positivity does not always determine clinical manifestations. The clinical relevance of positivity for these antibodies must take into account the type of positivity among those tested, the antibody titer, the persistence of positivity and the number of determinations where they are positive [ 30 , 31 , 32 , 33 , 34 ]. In our study, none of the subjects were diagnosed with antiphospholipid antibody syndrome.…”

Pulmonary hypertension complicating sarcoidosis

“…The rate of either IgG or IgM antiphospholipid serum antibodies reached 38% of sarcoidosis patients in the study of Ina et al, which was significantly upper than in healthy controls [41]. Several observations have described antiphospholipid syndrome occurring in sarcoidosis patients with [42] or without concomitant lupus [43,44]. Also, sarcoidosis can co-exist with various auto-immune disorders known to facilate thrombo-embolic disease and/or PAH, including Takayasu arteritis [45] and systemic scleroderma [46].…”

Sarcoidosis and antiphospholipid syndrome: A rare association

“…[1] Antiphospholipid syndrome (APS) is a clinical condition characterized by recurrent thrombotic events and/or pregnancy morbidity associated with the persistence of antiphospholipid antibodies. [2] The relationship of sarcoidosis and APS is not clearly understood and the possibility of these two entities share pathophysiological mechanisms has been explored.…”