A Patient with Lung Squamous Cell Carcinoma Presenting with Severe Cardiac Dysfunction Similar to Dilated Cardiomyopathy with Left Bundle Branch Block Induced by Myocardial Metastasis

Ogino, Hirokazu; Nishimura, Naoki; Kitamura, Akihiro; Ishikawa, Genta; Okafuji, Kohei; Tomishima, Yutaka; Jinta, Torahiko; Yamazoe, Masahiro; Yang, Yang; Chohnabayashi, Naohiko

doi:10.2169/internalmedicine.53.2616

Cited by 5 publications

(4 citation statements)

References 11 publications

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“…retinol metabolism, arachidonic acid metabolism, linoleic acid metabolism and metabolism of xenobiotics by cytochrome p450). A report verified that it was similar in patients between with lung squamous cell carcinoma and dilated cardiomyopathy induced by myocardial metastasis (30). Besides, immunodeficiency and other immune reactions were critical in the occurrence and devel-opment of tumors.…”

Section: Discussionmentioning

confidence: 78%

Screening pathogenic genes in oral squamous cell carcinoma based on the mRNA expression microarray data

et al. 2018

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Oral squamous cell carcinoma (OSCC) is one of the most common malignancies and its survival rate has barely improved over the past few decades. The purpose of this study was to screen pathogenic genes of OSCC via microarray analysis. The mRNA expression microarray datasets (GSE2280 and GSE3524) were downloaded from the Gene Expression Omnibus (GEO) database. In GSE2280, there were 22 OSCC samples without metastasis and 5 OSCC samples with lymph node metastasis. In GSE3524, there were 16 OSCC samples and 4 normal tissue samples. The differentially expressed genes (DEGs) in OSCC samples with lymph node metastasis compared with those without metastasis (named as DEGs-1), and the DEGs in OSCC samples compared with normal tissue samples (named as DEGs-2), were obtained via limma package. The Database for Annotation, Visualization and Integrated Discovery (DAVID) was used to perform the functional enrichment analyses of DEGs-1 and DEGs-2. The miRNA-gene pairs of overlaps among DEGs were screened out with the TargetScan database, and the miRNA-gene regulated network was constructed by Cytoscape software. A total of 233 and 410 DEGs were identified in the sets of DEGs-1 and DEGs-2, respectively. DEGs-1 were enriched in 188 Gene Ontology (GO) terms and 8 Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways, and DEGs-2 were enriched in 228 GO terms and 6 KEGG pathways. In total, 126 nodes and 135 regulated pairs were involved in the miRNA-gene regulated network. Our study indicated that transglutaminase 2 (TGM2) and Islet 1 (ISL1) may be biomarkers of OSCC and their metastases. Moreover, it provided some potential pathogenic genes (e.g. P2RY2 and RAPGEFL1) in OSCC.

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Section: Discussionmentioning

confidence: 78%

Screening pathogenic genes in oral squamous cell carcinoma based on the mRNA expression microarray data

et al. 2018

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“…As a result, we found that different gene essentiality scores have different preferences for terms without loss of plausibility. For example, there was a patient reported as LUSC with severe cardiac dysfunction similar to dilated cardiomyopathy (16) which was successfully identified by WEAT using the phastCons score. Similarly, a case with lung cancer was found to be related to the dilated phase of hypertrophic cardiomyopathy (17) which was identified by WEAT using the gene importance calculator (GIC) score.…”

Section: Resultsmentioning

confidence: 99%

Toward comprehensive functional analysis of gene lists weighted by gene essentiality scores

Fan

Cui

2021

Preprint

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Gene functional enrichment analysis represents one of the most popular bioinformatics methods for annotating the pathways and function categories of a given gene list. Current algorithms for enrichment computation such as Fisher’s exact test and hypergeometric test totally depend on the category count numbers of the gene list and one gene set. In this case, whatever the genes are, they were treated equally. However, actually genes show different scores in their essentiality in a gene list and in a gene set. It is thus hypothesized that the essentiality scores could be important and should be considered in gene functional analysis. For this purpose, here we proposed WEAT (https://www.cuilab.cn/weat/), a weighted gene set enrichment algorithm and online tool by weighting genes using essentiality scores. We confirmed the usefulness of WEAT using two case studies, the functional analysis of one aging-related gene list and one gene list involved in Lung Squamous Cell Carcinoma (LUSC). Finally, we believe that the WEAT method and tool could provide more possibilities for further exploring the functions of given gene lists.

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“…Peluso et al noted a case of non-small cell lung cancer infiltrating the left ventricular apex and manifesting as atrial fibrillation [4]. Moreover at least two instances of ventricle myocardial metastases from primary lung cancer have been reported: Kinoshita et al reported squamous cell lung cancer leading to ventricular tachycardia secondary to right ventricle myocardial metastases [5] while Ogino et al described squamous cell cancer leading to new LBBB with myocardial metastases on autopsy [6]. Unlike benign non-infiltrating tumors which cause arrhythmia by mechanical stretching of myocardial fibers, invasive tumors can cause intramyocardial metastases which can alter the conduction pathways and trigger automaticity.…”

Section: Discussionmentioning

confidence: 99%

Stage IV Non-small Cell Lung Cancer Presenting as Supraventricular Tachycardia

Amin¹,

Chaudhuri²

2019

Cureus

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Despite numerous advancements in diagnostics and treatment, lung cancer carries a high mortality rate. This is primarily attributable to the fact that the majority of patients present with stage III or IV disease and otherwise non-specific symptoms. In this article, we discuss a rare case of stage IV lung cancer presenting as supraventricular tachycardia secondary to cardiomediastinal involvement. Unfortunately, by the time the tumor had involved the mediastinum, surgical options were limited and treatment was largely palliative.

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A Patient with Lung Squamous Cell Carcinoma Presenting with Severe Cardiac Dysfunction Similar to Dilated Cardiomyopathy with Left Bundle Branch Block Induced by Myocardial Metastasis

Cited by 5 publications

References 11 publications

Screening pathogenic genes in oral squamous cell carcinoma based on the mRNA expression microarray data

Screening pathogenic genes in oral squamous cell carcinoma based on the mRNA expression microarray data

Toward comprehensive functional analysis of gene lists weighted by gene essentiality scores

Stage IV Non-small Cell Lung Cancer Presenting as Supraventricular Tachycardia

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