A patient with central nervous system tuberculomas and a history of disseminated multi-drug-resistant tuberculosis

Abstract

Tuberculosis (TB) is one of the leading causes of death worldwide, particularly in low- and middle-income countries. The global rates and numbers of drug resistant TB are rising. With increasing globalization, the spread of drug-resistant strains of TB has become a mounting global public health concern. We present a case of a young man previously treated for multi-drug resistant (MDR) TB in India who presented with neurological symptoms and central nervous system TB in the United States. His case highlights unique diagnostic and treatment challenges that are likely to become more commonplace with the increase of patients infected with drug-resistant TB and complicated extrapulmonary disease.

Drug-resistant strains of Mycobacterium tuberculosis: cell envelope profiles and interactions with the host

“…Several studies involving extrapulmonary TB indicate that the rate of DR-TB in these patients goes between 4.4% to 20% (Dusthackeer et al, 2015). Similar to extrapulmonary TB, cases of disseminated DR-TB are reported around the world and can also complicate the already difficult-to-manage problem of DR-TB (Jung et al, 2016;Kaplan et al, 2018).…”

Genetic Factors Associated With Mutations of Molecular Mechanism and Drug Resistance in Mycobacterium Tuberculosis

“…Co-infection is actually a type of infection which cause due to multiple pathogen species and when TB which is mostly co-infect with HIV developed than it's led to enhance strains of XDR-TB and MDR-TB strains. Because when both disease cause at the same time than its latent or active TB disease and its cause resistance against TB drugs (Kaplan et al, 2018). Due to this co-infection of HIV and TB rate of TB infections gets high triplet times in Africa.…”

Facile in situ generation of bismuth tungstate nanosheet-multiwalled carbon nanotube composite as unconventional affinity material for quartz crystal microbalance detection of antibiotics

“…Being one of the top 10 causes of deaths worldwide, tuberculosis is arguably the most important disease to target. This situation gets worse as about 480,000 people were reported to develop multidrug-resistant tuberculosis merely in 2015 [2,3]. In this connection, rifampicin (RIF) is an important drug as it is widely used in the treatment of bacterial infections to treat or prevent tuberculosis [4].…”