A pathophysiologic study of tako-tsubo cardiomyopathy with F-18 fluorodeoxyglucose positron emission tomography

Yoshida, Tetsuro; Hibino, Takeshi; Kako, Nobuo; Murai, Shunsuke; Oguri, Mitsutoshi; Kato, Koichi; Yajima, Kazuhiro; Ohte, Nobuyuki; Yokoi, Kiyoshi; Kimura, Genjiro

doi:10.1093/eurheartj/ehm401

Cited by 159 publications

(127 citation statements)

References 41 publications

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“…Other authors demonstrated, in patients with TS, abnormalities of the microcirculation through myocardial perfusion scintigraphy with technetium 99 m tetrofosmin (20)(21)(22). A disorder of glucose and fatty acid metabolism, even more, severe of the perfusion defect, has also been demonstrated (23)(24). Abnormalities of coronary microcirculation have been also detected using contrast echocardiography (25)(26).…”

Section: Discussionmentioning

confidence: 93%

Characteristics of coronary microcirculatory function in patients with Takotsubo syndrome

et al. 2017

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Background: Takotsubo syndrome (TS) is a recently described cardiac syndrome whose pathogenesis is still unclear. We investigated the characteristics of coronary microcirculatory function in patients with TS through the analysis of the TIMI frame count (TFC) compared to normal subjects and with to subjects with microvascular angina (MA). Conclusions: Coronary microcirculation in TS patients is diffuse and milder compared to MA patients.Cut-off values >20 frames discriminate between patients with normal microcirculation and patients with TS.

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Section: Discussionmentioning

confidence: 93%

Characteristics of coronary microcirculatory function in patients with Takotsubo syndrome

et al. 2017

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“…Studies measuring myocardial perfusion via TIMI myocardial perfusion grade (TMPG) as well as nuclear imaging have demonstrated coronary microcirculatory disturbances. [9,10] It has been hypothesized that these microvascular abnormalities may result from increased mechanical wall stress as a consequence of apical ballooning. [11] Nonetheless, these abnormalities may manifest as abnormal nuclear stress tests, as in our case, and stress tests should be interpreted with caution in patients with stress cardiomyopathy.…”

Section: Discussionmentioning

confidence: 99%

A case of takotsubo cardiomyopathy in a patient with anaphylaxis treated with epinephrine

Thind

Patel

Patri

et al. 2017

CRIM

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Takotsubo cardiomyopathy (TTC) is a recently identified transient cardiomyopathy that is usually associated with emotional or physical stress. Catecholamine surge appears to be central to the mechanism of TTC. TTC in the setting of anaphylaxis is rare. We present a case of a 58-year-old female was referred from an outside hospital after being diagnosed with anaphylaxis. She received 0.3 mg epinephrine intramuscularly and 1 mg intravenously. Upon admission to our hospital, she was complaining of chest pain. EKG done in the outside hospital showed ST elevations in the anterior leads but the EKG done at our hospital was normal. She had to be intubated in view of impending airway obstruction. She was subsequently started on epinephrine infusion in the intensive care unit for hypotension. She was found to have elevated troponins that trended up. An echocardiogram performed on day 3 revealed a left ventricular ejection fraction of 25% and apical hypokinesis suggestive of TTC. Cardiac catheterization was initially deferred in view of a history of dye allergy. A nuclear stress test was done instead that revealed reversible ischemia in anteroseptal regions. Cardiac catheterization was performed eventually with pre-medication that showed a near-normal coronary circulation. A repeat echocardiogram performed 6 weeks after discharge showed normal systolic function.

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“…Another hypothesis is coronary microvascular dysfunction [12] . Impaired microvascular function and myocardial metabolic disturbances have been found in patients with TS on basis of thallium-201 and 18 F-fluorodeoxyglucose myocardial scans [13] .…”

Section: Discussionmentioning

confidence: 99%

A Variant form of Takotsubo Syndrome secondary to Sumatriptan: A case report

Rathore

Deleon

2014

CRIM

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Takotsubo syndrome (TS), also known as stress-induced cardiomyopathy or broken heart syndrome, is an acute reversible left ventricular systolic dysfunction that mimics an acute coronary syndrome. It has various types and mechanism of pathogenesis is not very well defined. It is more common in postmenopausal women and is associated with emotional or physical stress. We report a case of type III takotsubo syndrome in a postmenopausal woman after taking sumatriptan for migraine headache.

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A pathophysiologic study of tako-tsubo cardiomyopathy with F-18 fluorodeoxyglucose positron emission tomography

Abstract: The extent of metabolic defect involving apical akinetic area was more severe than perfusion abnormality. Our data suggest that sudden emotional or physical stress may cause a catecholamine-induced metabolic disorder in the myocardium, which is probably central to this syndrome.

Cited by 159 publications

References 41 publications

Characteristics of coronary microcirculatory function in patients with Takotsubo syndrome

Characteristics of coronary microcirculatory function in patients with Takotsubo syndrome

A case of takotsubo cardiomyopathy in a patient with anaphylaxis treated with epinephrine

A Variant form of Takotsubo Syndrome secondary to Sumatriptan: A case report

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