A Pathomimetic Colorectal Tumor‐on‐a‐Chip for In Vitro Reconstitution of the Primary Colorectal Cancer (Adv. Mater. Technol. 13/2023)

Abstract

Tumor on a Chip In article number 2200758, Lu Huang and co‐workers propose a pathomimetic colorectal tumor‐on‐a‐chip (CRT‐chip) that can effectively recapitulate the in vivo dynamic physiology and pathology of primary colorectal cancer (CRC). The cover figure demonstrates the analogy between the CRT‐chips and the in vivo primary CRC. The central channel seeded with epithelial cells mimics the epithelium layer of colorectum. The tumor cells loaded in the microchamber emulate the site‐specific primary CRC. The bottom channel underneath the microchamber recapitulates the in vivo tumor vessels.

Biomimetic Exogenous “Tissue Batteries” as Artificial Power Sources for Implantable Bioelectronic Devices Manufacturing

“…In modern medicine, batteries are crucial components of implanted electronic devices, providing a reliable and convenient source of energy for various bioelectronic devices, including artificial muscles, bioelectronic prostheses, blood glucose monitors, neurostimulators, pacemakers, defibrillators, and cochlear implants. [166,167] For IBDs, there are special requirements for ATBs, which must be small, lightweight, long-lasting, highenergy-density, and biosafe with excellent cycling stability to ensure continuous operation in vivo. [168,169] Moreover, they must be hermetically sealed to prevent any potential chemical leakage and discharge indication, with excellent compatibility with the soft properties of human tissue.…”

Biofluid‐Activated Biofuel Cells, Batteries, and Supercapacitors: A Comprehensive Review

“…The redox reaction in the conjugated polymers and high con-ductivity of the electrode allowed for both pseudocapacitance and electrochemical double-layer (EDL) formation to occur on the surface of PEDOT:PSS electrode. As shown in Figure 4b, as cations from the sweat electrolyte (Na + or K + ) enter the PE-DOT:PSS channel, the oxidized PEDOT + reduces to its natural state by ion exchange with the sweat electrolyte, as given by Equation (20).…”

“…Tissue-integrated devices are an important class of biomedical instruments that aid in optimizing performance of the human body. [1][2][3][4][5][6][7][8] These devices include wearable and implantable biochemical and biophysical sensors, [9][10][11][12][13][14][15][16] drug delivery platforms, [17][18][19] and organ function optimizing devices, such as pacemakers [20,21] and implantable cardiac defibrillators. [22][23][24] DOI: 10.1002/adma.202303197 Tissue-integrated sensors enable close monitoring of various metabolic, electrolytic, proteomic, electrical, kinematic, thermal, and vascular dynamics parameters which provide unprecedented insights into the biological processes occurring within the body.…”