A Path Breaking Method for Dermal Absorption of Drugs

Abstract

Aim: To develop a method for studying the dermal absorption of topical preparations. Method: Multi-level filter paper based method was employed for the present study. The method was developed in house. The permeation of the dermatological products from top layer to bottom layer was evaluated and the presence of active principles was confirmed using UV lamp. S.aureus was used to check the molecular size similarity of the active principle. Results: The dermal absorption of the actives was greater from ointment base when compared to cream base. Discussion: The greater dermal absorption of actives from ointment base coupled with the greater retention time of the ointment support the ointment base to be the best vehicle for delivering fat soluble herbal drugs. The present study also highlights the scientific credibility, reliability, ease of use, cost advantage of multilayered filter paper method developed by us for testing the dermal absorption of topical drugs. Conclusion: The present study undoubtedly established the reliability and reproducibility of the method.