Differential evolution (DE) has been extensively used in optimization studies since its development in 1995 because of its reputation as an effective global optimizer. DE is a population-based metaheuristic technique that develops numerical vectors to solve optimization problems. DE strategies have a significant impact on DE performance and play a vital role in achieving stochastic global optimization. However, DE is highly dependent on the control parameters involved. In practice, the fine-tuning of these parameters is not always easy. Here, we discuss the improvements and developments that have been made to DE algorithms. The Multi-Layer Strategies Differential Evolution (MLSDE) algorithm, which finds optimal solutions for large scale problems. To solve large scale problems were grouped different strategies together and applied them to date set. Furthermore, these strategies were applied to selected vectors to strengthen the exploration ability of the algorithm. Extensive computational analysis was also carried out to evaluate the performance of the proposed algorithm on a set of well-known CEC 2015 benchmark v functions. This benchmark was utilized for the assessment and performance evaluation of the proposed algorithm. vi ACKNOWLEDGEMENTS Special appreciations to my family. Words cannot express how thankful I am to my wife, my daughters, my mother, my mother-in law, and father-in-law for all of the sacrifices and prayers for me that you've made on my behalf. I would like to express my special thanks to my advisor Professor Ausif Mahmood and his efforts, encouraging and guiding me to grow as a research scientist.. vii