A paraganglioma in the posterior wall of the left atrium originating from the aortic body in a Wistar Hannover rat

Li, Yinghua; Shiraiwa, Kazumi; Ko, Kyeong-Nam; Moon, Jemin; Lee, Miju; Shin, Sunhee; Kim, Myoungjun; Jang, Ho-Song; Lee, Yonghoon; Kim, Duyeol; Kang, Jin Seok; Kang, Jong-Koo

doi:10.1016/j.etp.2012.07.002

Cited by 5 publications

(4 citation statements)

References 15 publications

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“…Their morphology and location are distinctive features (Alison et al 1987; Li et al 2013). These neoplasms are reportedly immunoreactive for synaptophysin and Chromogranin A (Li et al 2013). …”

Section: Nomenclature Diagnostic Criteria and Differential Diagnosesmentioning

confidence: 99%

Non-proliferative and Proliferative Lesions of the Cardiovascular System of the Rat and Mouse

Berridge

Mowat²,

Nagai

et al. 2016

J Toxicol Pathol

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The INHAND Project (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice) is a joint initiative of the Societies of Toxicologic Pathology from Japan (JSTP), Europe (ESTP), Great Britain (BSTP) and North America (STP) to develop an internationally-accepted nomenclature for proliferative and non-proliferative lesions in laboratory animals. The primary purpose of this publication is to provide a standardized nomenclature for characterizing lesions observed in the cardiovascular (CV) system of rats and mice commonly used in drug or chemical safety assessment. The standardized nomenclature presented in this document is also available electronically for society members on the internet (http://goreni.org). Accurate and precise morphologic descriptions of changes in the CV system are important for understanding the mechanisms and pathogenesis of those changes, differentiation of natural and induced injuries and their ultimate functional consequence. Challenges in nomenclature are associated with lesions or pathologic processes that may present as a temporal or pathogenic spectrum or when natural and induced injuries share indistinguishable features. Specific nomenclature recommendations are offered to provide a consistent approach.

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Section: Nomenclature Diagnostic Criteria and Differential Diagnosesmentioning

confidence: 99%

Non-proliferative and Proliferative Lesions of the Cardiovascular System of the Rat and Mouse

Berridge

Mowat²,

Nagai

et al. 2016

J Toxicol Pathol

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“…While pheochromocytomas are relatively rare in animal models, they do occur on a regular basis, both spontaneously or as a result of chemical or radiological induction in rats and mice (in fact, the toxicology literature contains important information often overlooked by researchers) and on a wide variety of genetically modified backgrounds in mice (Warren & Chute 1972, DeLellis et al 1973, Pellegata et al 2006, Greim et al 2009. Paragangliomas on the other hand, defined here as non-adrenal tumors originating in any paraganglia, are relatively rare in rats and mice (van Zwieten et al 1979, Hall et al 1987, Pirak et al 1988, Li et al 2013 and the systematic development of these tumors has only been reported in B6/CD1 B-Raf +/LSLV600E mice, occurring exclusively on an F1 hybrid B6/CD1 background (Urosevic et al 2011).…”

Section: Rodent-derived Cell Modelsmentioning

confidence: 99%

Advances in paraganglioma–pheochromocytoma cell lines and xenografts

Bayley

Devilee

2020

Endocrine-Related Cancer

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This review describes human and rodent-derived cell lines and xenografts developed over the last five decades that are suitable or potentially suitable models for paraganglioma-pheochromocytoma research. We outline the strengths and weaknesses of various models and emphasize the recurring theme that, despite the major challenges involved, more effort is required in the search for valid human and animal cell models of paraganglioma-pheochromocytoma, particularly those relevant to cancers carrying a mutation in one of the succinate dehydrogenase genes. Despite many setbacks, the recent development of a potentially important new model, the RS0 cell line, gives reason for optimism regarding the future of models in the paraganglioma-pheochromocytoma field. We also note that classic approaches to cell line derivation such as SV40-mediated immortalization and newer approaches such as organoid culture or iPSCs have been insufficiently explored. As many existing cell lines have been poorly characterized, we provide recommendations for reporting of paraganglioma and pheochromocytoma cell lines, including the strong recommendation that cell lines are made widely available via the ATCC or a similar cell repository. Basic research in paraganglioma-pheochromocytoma is currently transitioning from the analysis of genetics to the analysis of disease mechanisms and the clinically-exploitable vulnerabilities of tumors. A successful transition will require many more disease-relevant human and animal models to ensure continuing progress.

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“…There are a handful of prior publications about paragangliomas in rats. There are several case studies describing tumors in 1 or 2 animals (Bhandari 1982;Li et al 2013;Trevino and Nessmith 1972), and a comprehensive review of paragangliomas, focusing on F344/N rats from the NTP and National Figure 7I-J. H&E-stained longitudinal sections of incisor teeth from Sprague Dawley rats from a 1-month toxicity study.…”

Section: Location Location Locationmentioning

confidence: 99%

“…There are a handful of prior publications about paragangliomas in rats. There are several case studies describing tumors in 1 or 2 animals (Bhandari 1982; Li et al 2013; Trevino and Nessmith 1972), and a comprehensive review of paragangliomas, focusing on F344/N rats from the NTP and National Cancer Institute programs (Hall, Yoshitomi, and Boorman 1987). Key points from the Hall et al paper are that paragangliomas are uncommon in most strains of rats, and there is a male predominance (Hall, Yoshitomi, and Boorman 1987).…”

Section: Location Location Locationmentioning

confidence: 99%

Proceedings of the 2017 National Toxicology Program Satellite Symposium

Elmore

Aeffner

Bangari³

et al. 2017

Toxicol Pathol

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The 2017 annual National Toxicology Program Satellite Symposium, entitled “Pathology Potpourri,” was held in Montreal, Quebec, Canada, at the Society of Toxicologic Pathology's (STP) 36th annual meeting. The goal of this symposium was to present and discuss challenging diagnostic pathology and/or nomenclature issues. This article presents summaries of the speakers' talks, along with select images that were used by the audience for voting and discussion. Various lesions and other topics covered during the symposium included renal papillary degeneration in perinatally-exposed animals; an atriocaval mesothelioma; an unusual presentation of an alveolar bronchiolar carcinoma; a paraganglioma of the Organ of Zuckerkandl, also called an extra adrenal pheochromocytoma; the use of human muscle samples to illustrate the challenges of manual scoring of fluorescent staining; intertubular spermatocytic seminomas; medical device pathology assessment and discussion of the approval process; collagen induced arthritis; incisor denticles; ameloblast degeneration and poorly mineralized enamel matrix; connective tissue paragangliomas; microcystin LR toxicity; perivascular mast cells in the forebrain thalamus unrelated to treatment; and two cases that provided a review of the International Harmonization of Nomenclature and Diagnostic Criteria (INHAND) bone nomenclature and recommended application of the terminology in routine nonclinical toxicity studies.

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A paraganglioma in the posterior wall of the left atrium originating from the aortic body in a Wistar Hannover rat

Cited by 5 publications

References 15 publications

Non-proliferative and Proliferative Lesions of the Cardiovascular System of the Rat and Mouse

Non-proliferative and Proliferative Lesions of the Cardiovascular System of the Rat and Mouse

Advances in paraganglioma–pheochromocytoma cell lines and xenografts

Proceedings of the 2017 National Toxicology Program Satellite Symposium

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