A paradigm shift of the conventional intramedullary devices to new biological osteosynthetic devices: Bone stents

Munib, Zainab; Ansari, Umair; Ali, Murtaza Najabat; Rana, Nosheen Fatima

doi:10.7439/ijbar.v5i3.596

Cited by 2 publications

(1 citation statement)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Frequently in orthopaedics, the use of bone stents is necessary to heal traumatic bone injuries. 1 Recent advances in biomedical imaging analysis and bioprinting have made it possible to create custom bone stent scaffolds based on patient imaging for use as implantable biological scaffolds for musculoskeletal applications. 2 The technology can also be extended for use in soft tissues associated with bone, such as spinal discs.…”

Section: Introductionmentioning

confidence: 99%

Methods for modeled bioprinting of hard and soft tissues

Campos,

Datto,

Liu

et al. 2024

Medical Imaging 2024: Imaging Informatics for Healthcare, Research, and Applications

View full text Add to dashboard Cite

This study presents new methods to utilize bioprinting technology to recreate hard and soft tissue based on medical imaging. Using the proposed methods, medical DICOM files are converted into STL files and bioprinted into PCL:HA scaffolds. The high model precision provides potential for their use as image-based, implantable biological scaffolds for musculoskeletal applications.Initially, femur segments were recreated for the hard tissue model and spinal discs for the soft tissue model. All models were bioprinted utilizing PCL:HA ratios of 80:20 for ease of manufacturing. Printing methodology circumvents the need for solvents in PCL printing, allowing for scaffolds to be created in a safer, faster, and more cost-effective manner.For the hard tissue models, DICOM files are converted directly into STL files utilizing the software 3D Slicer. The software directly segments the imaging to print a specified section of hard tissue. For soft tissue models, a protocol called negative imaging was created to generate soft tissue models based on hard tissue imaging. This method is employed due to the difficulty of isolating soft tissue, such as spinal discs, in DICOM files. The protocol utilizes CAD to generate a mold of the soft tissue from the surrounding hard tissue. The mold is then cleaned in Meshmixer to fix imperfections.To gauge the strength of various PCL:HA ratios for future tissue models, PCL:HA ratios from 90:10 to 65:35 were printed into standardized cubes and compression tested to determine stiffness. Various infill geometries were also tested to see their effect on the scaffold stiffness.

show abstract

Section: Introductionmentioning

confidence: 99%