A paradigm shift in the treatment of emotional memory disorders: Lessons from basic science

Kindt, Merel; Elsey, James W. B.

doi:10.1016/j.brainresbull.2022.11.019

Cited by 4 publications

(3 citation statements)

References 66 publications

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“…While in adolescent mice, no significant differences were observed after MLT treatment, in the coherence between the mPFC and the dHippo, in adult mice, we found an increased synchronization in the lower frequencies, corresponding to delta and low-theta bands. Although mPFC is known to be highly correlated with the ventral hippocampus in anxiety [ 61 ], we opted to record the correlation between the mPFC and the dHippo mainly due to (1) the high presence of MLT receptors in both the mPFC and the rostral rather than the ventral region of the hippocampus [ 25 , 26 ], (2) the fact that preliminary work has suggested a possible role for the dHippo in the anxiolytic effects of MLT [ 62 ], (3) acting on the process of memory reconsolidation in which the dHippo plays a major role [ 63 ] and appears to be a novel promising strategy for treating anxiety disorders [ 64 ]. Remarkably, recent studies have demonstrated that direct functional projections from the dorsal hippocampus to the prelimbic cortex are necessary for strengthening aversive memory through different molecular mechanisms [ 65 , 66 ], while increased theta coherence is observed during spatial memory tasks and after the application of dopamine in mPFC [ 67 ].…”

Section: Discussionmentioning

confidence: 99%

Age-Related Effects of Exogenous Melatonin on Anxiety-like Behavior in C57/B6J Mice

Nasini,

Tidei,

Shkodra

et al. 2023

Biomedicines

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The synthesis of melatonin (MLT) physiologically decreases during aging. Treatment with MLT has shown anxiolytic, hypnotic, and analgesic effects, but little is known about possible age-dependent differences in its efficacy. Therefore, we studied the effects of MLT (20 mg/kg, intraperitoneal) on anxiety-like behavior (open field (OFT), elevated plus maze (EPMT), three-chamber sociability, and marble-burying (MBT) tests), and the medial prefrontal cortex (mPFC)-dorsal hippocampus (dHippo) circuit in adolescent (35–40 days old) and adult (three-five months old) C57BL/6 male mice. MLT did not show any effect in adolescents in the OFT and EPMT. In adults, compared to vehicles, it decreased locomotor activity and time spent in the center of the arena in the OFT and time spent in the open arms in the EPMT. In the MBT, no MLT effects were observed in both age groups. In the three-chamber sociability test, MLT decreased sociability and social novelty in adults, while it increased sociability in adolescents. Using local field potential recordings, we found higher mPFC-dHippo synchronization in the delta and low-theta frequency ranges in adults but not in adolescents after MLT treatment. Here, we show age-dependent differences in the effects of MLT in anxiety paradigms and in the modulation of the mPFC-dHippo circuit, indicating that when investigating the pharmacology of the MLT system, age can significantly impact the study outcomes.

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Section: Discussionmentioning

confidence: 99%

Age-Related Effects of Exogenous Melatonin on Anxiety-like Behavior in C57/B6J Mice

Nasini,

Tidei,

Shkodra

et al. 2023

Biomedicines

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“…Therefore, we will include emotional and physiological measures of arousal (eg, subjective distress and heart rate variability (HRV)36 37) to explore conditions enabling a successful implementation of a BI-VT in the perinatal context. In the future, such an assessment of physiological/emotional arousal could guide a personalised adaptation of this type of intervention 38…”

Section: Introductionmentioning

confidence: 99%

“…In the future, such an assessment of physiological/emotional arousal could guide a personalised adaptation of this type of intervention. 38 …”

Section: Introductionmentioning

confidence: 99%

Tackling childbirth-related intrusive memories with a single-session behavioural intervention involving a visuospatial task: protocol for a single-blind, waitlist-controlled randomised trial

et al. 2023

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IntroductionApproximately 12.3% of mothers experience childbirth-related post-traumatic stress symptoms (CB-PTSS). However, evidence-based interventions to treat CB-PTSS are lacking. Intrusive memories (IM), a key CB-PTSS, are distressing and can trigger other PTSS by reliving the traumatic event. Emerging evidence shows that a behavioural intervention involving a visuospatial task (BI-VT) can reduce the number of IM and PTSS, supposedly by interfering with the reconsolidation of the trauma memory. This study aims to test the efficacy of a single-session BI-VT targeting IM to reduce the number of childbirth-related (CB-)IM and PTSS, in comparison to a waitlist control group (WCG).Methods and analysisIn this multicentre, single-blind, randomised controlled trial being undertaken at one regional and one university hospital in Switzerland, 60 participants will be allocated to the Immediate Intervention Group (IIG), receiving the immediate intervention on day 15, and 60 participants to the WCG receiving the delayed intervention on day 30. All participants will report their CB-IM during the 2 weeks preimmediate and postimmediate intervention in diaries. The IIG will additionally report their CB-IM over weeks 5 and 6 postimmediate intervention. Self-report questionnaires will assess CB-PTSS at 2 weeks preimmediate and postimmediate intervention in both groups, and at 6 weeks postimmediate intervention in the IIG. A feedback questionnaire will evaluate the intervention acceptability. The primary outcome will be group differences in the number of CB-IM between the 2 weeks preimmediate and postimmediate intervention. Secondary outcomes will be CB-PTSS at 2 and 6 weeks postimmediate intervention, the number of CB-IM at weeks 5 and 6 postimmediate intervention, and intervention acceptability.Ethics and disseminationEthical approval was granted by the Human Research Ethics Committee of the Canton of Vaud (study number 202200652). Participants will provide an informed consent before study participation. Results will be presented in peer-reviewed journals and at conferences.Trial registration numberNCT05381155.

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Editorial: Special Issue honouring Karim Nader’s contributions to memory research

Frankland¹

2023

Brain Research Bulletin

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A paradigm shift in the treatment of emotional memory disorders: Lessons from basic science

Cited by 4 publications

References 66 publications

Age-Related Effects of Exogenous Melatonin on Anxiety-like Behavior in C57/B6J Mice

Age-Related Effects of Exogenous Melatonin on Anxiety-like Behavior in C57/B6J Mice

Tackling childbirth-related intrusive memories with a single-session behavioural intervention involving a visuospatial task: protocol for a single-blind, waitlist-controlled randomised trial

Editorial: Special Issue honouring Karim Nader’s contributions to memory research

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