A paper sensor for unbound valproic acid detection in human serum

Abstract

Valproic acid (VPA) is mainly used in the clinic to treat epilepsy, for which the therapeutic window is narrow to avoid causing adverse reactions such as hepatotoxicity and teratogenicity. Therefore,...

A simple and rapid HPLC-UV method for the determination of valproic acid in human plasma using microwave-assisted derivatization with phenylhydrazine hydrochloride

“…Immunological tests have been developed for easy and fast analysis. For example, colloidal gold-based immunochromatographic strips have been developed as a rapid qualitative detection technique for VPA [ 11 ]. Some immunoassays for quantitative purposes have also been developed, such as fluorescence polarization immunoassay (FPIA) with a sensitivity of 4.4 μg/mL [ 12 ] and enzyme-multiplied immunoassay (EMIT) with a sensitivity of 1.0 μg/mL [ 13 ].…”