A Panoramic View of Cell Population Dynamics in Mammalian Aging
Zehao Zhang,
Chloe Schaefer,
Weirong Jiang
et al.
Abstract:To elucidate the aging-associated cellular population dynamics throughout the body, here we present PanSci, a single-cell transcriptome atlas profiling over 20 million cells from 623 mouse tissue samples, encompassing a range of organs across different life stages, genders, and genotypes. This comprehensive dataset allowed us to identify more than 3,000 unique cellular states and catalog over 200 distinct aging-associated cell populations experiencing significant depletion or expansion. Our panoramic analysis … Show more
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