A pangenome analysis of ESKAPE bacteriophages: the underrepresentation may impact machine learning models
Jeesu Lee,
Branden Hunter,
Hyunjin Shim
Abstract:Bacteriophages are the most prevalent biological entities in the biosphere. However, limitations in both medical relevance and sequencing technologies have led to a systematic underestimation of the genetic diversity within phages. This underrepresentation not only creates a significant gap in our understanding of phage roles across diverse biosystems but also introduces biases in computational models reliant on these data for training and testing. In this study, we focused on publicly available genomes of bac… Show more
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