A pan-tissue, pan-disease compendium of human orphan genes
Urminder Singh,
Jeffrey A. Haltom,
Joseph W. Guarnieri
et al.
Abstract:Species-specific genes are ubiquitous in evolution, with functions ranging from prey paralysis to survival in subzero temperatures. Because they are typically expressed under limited conditions and lack canonical features, such genes may be vastly under-identified, even in humans. Here, we leverage terabytes of human RNA-Seq data to identify thousands of highly-expressed transcripts that do not correspond to any Gencode-annotated gene. Many may be novel ncRNAs although 80% of them contain ORFs that have the po… Show more
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