A pan-cancer analysis of the oncogenic role of leucine zipper protein 2 in human cancer

Feng, Dechao; Shi, Xu; Zhu, Weizhen; Zhang, Facai; Li, Dengxiong; Han, Ping; Wei, Qiang; Yang, Lu

doi:10.1186/s40164-022-00313-x

Cited by 19 publications

(12 citation statements)

References 11 publications

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“…LUZP2 , a leucine zipper protein, is associated with Alzheimer’s Disease and schizophrenia, as well as cognitive performance in the normal elderly population 43 . It is differentially expressed in several cancers, including low grade gliomas 44 . Similarly, RERGL is differentially expressed in schizophrenia 45 , while its expression is significantly higher in meningiomas compared to healthy tissue 46 .…”

Section: Resultsmentioning

confidence: 99%

Cell type-specific gene expression dynamics during human brain maturation

Steyn,

Mishi,

Fillmore

et al. 2023

Preprint

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The human brain undergoes protracted post-natal maturation, guided by dynamic changes in gene expression. To date, studies exploring these processes have used bulk tissue analyses, which mask cell type-specific gene expression dynamics. Here, using single nucleus (sn)RNA-seq on temporal lobe tissue, including samples of African ancestry, we build a joint paediatric and adult atlas of 54 cell subtypes, which we verify with spatial transcriptomics. We explore the differences in cell states between paediatric and adult cell types, revealing the genes and pathways that change during brain maturation. Our results highlight excitatory neuron subtypes, including the LTK and FREM subtypes, that show elevated expression of genes associated with cognition and synaptic plasticity in paediatric tissue. The new resources we present here improve our understanding of the brain during a critical period of its development and contribute to global efforts to build an inclusive cell map of the brain.

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Section: Resultsmentioning

confidence: 99%

Cell type-specific gene expression dynamics during human brain maturation

Steyn,

Mishi,

Fillmore

et al. 2023

Preprint

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“…In comparison to normal samples, we found that the LUZP2 mRNA expression was significantly higher in PRAD. In terms of overall survival, low expression of LUZP2 was significantly associated with poor prognosis in PRAD [29]. However, the effect of LUZP2 on PD has not been reported, which may be a new marker for PD treatment.…”

Section: Discussionmentioning

confidence: 99%

Parkinson’s Disease as a Risk Factor for Prostate Adenocarcinoma: A Molecular Point of View

Liu¹,

Yang²,

Liu³

et al. 2023

Gerontology

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Introduction: Cancer and neurodegeneration are two major leading causes of morbidity and death worldwide. Neurodegeneration results in excessive neuronal cell death, and cancer emerges from increased proliferation and resistance to cell death. Although most epidemiological studies support an inverse association between the risk for the development of neurodegenerative diseases and cancer, increasing evidence points to a positive correlation between specific types of cancer, like prostate adenocarcinoma (PRAD), and neurodegenerative diseases, like Parkinson’s disease (PD). Methods: PD and PRAD differential genes were screened through the GEO database, and the differential genes were analyzed using David, String, GEPIA, Kaplan-Meier plotter, TIMER2.0, proteinatlas, cBioPortal, and CTD databases. To elucidate the biological function and molecular mechanism of PD and PRAD-related genes. Results: Studies have shown that the hub gene and differentially expressed genes (DEGs) in PD were differentially expressed in PRAD, including CDC20, HSPA4L, ROBO1, DMKN, IFI27L2, LUZP2, PTN, PTGDS. In PRAD, the high expression of HSPA4L, ROBO1, DMKN, IFI27L2, PTN, and PTGDS genes were associated with longer survival, while the patients with low expression of CDC20 and LUZP2 genes have longer survival. The mRNA of CDC20 and LUZP2 were highly expressed, while the mRNA of HSPA4L, ROBO1, DMKN, IFI27L2, and PTGDS were low expressed. Gene methylation did not affect the survival of patients. The high expression of miR-142, miR-186, miR-30a, miR-497, miR-590, miR-28, and miR-576 in micro RNA (miRNA) might potentially be used as biomarkers for the progression of PD and PRAD, and for the early diagnosis of PD and PRAD in the populations. The genes in this study were highly associated with B cells, CD8+ T cells, CD4+ T cells, macrophages, neutrophils, and dendritic cells. Somatic mutation mainly focused on missense mutation. Therapeutic drugs included Acetaminophen and Valproic Acid (VPA). Conclusion: Bioinformatics was used to identify potential targets and novel molecular mechanisms that may serve as clinical markers for the diagnosis and treatment of PD and PRAD.

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“…For tumor heterogeneity, we compared homologous recombination deficiency (HRD), loss of heterozygosity (LOH), neoantigen (NEO), tumor ploidy, tumor purity, mutant-allele tumor heterogeneity (MATH), tumor mutation burden (TMB) and microsatellite instability (MSI) [ 43 , 44 ] between two subtypes. All these data could be obtained from our previous study [ 9 ]. In addition, for the TIME analysis, we used Cibersortx and ESTIMATE algorithms [ 45 – 47 ] to assess the overall tumor microenvironment and immune components and compared the differences of tumor microenvironment scores and 54 immune checkpoints between these two subtype.…”

Section: Methodsmentioning

confidence: 99%

Membrane tension-mediated stiff and soft tumor subtypes closely associated with prognosis for prostate cancer patients

Wang

Shi

et al. 2023

Eur J Med Res

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Background Prostate cancer (PCa) is usually considered as cold tumor. Malignancy is associated with cell mechanic changes that contribute to extensive cell deformation required for metastatic dissemination. Thus, we established stiff and soft tumor subtypes for PCa patients from perspective of membrane tension. Methods Nonnegative matrix factorization algorithm was used to identify molecular subtypes. We completed analyses using software R 3.6.3 and its suitable packages. Results We constructed stiff and soft tumor subtypes using eight membrane tension-related genes through lasso regression and nonnegative matrix factorization analyses. We found that patients in stiff subtype were more prone to biochemical recurrence than those in soft subtype (HR 16.18; p < 0.001), which was externally validated in other three cohorts. The top ten mutation genes between stiff and soft subtypes were DNAH, NYNRIN, PTCHD4, WNK1, ARFGEF1, HRAS, ARHGEF2, MYOM1, ITGB6 and CPS1. E2F targets, base excision repair and notch signaling pathway were highly enriched in stiff subtype. Stiff subtype had significantly higher TMB and T cells follicular helper levels than soft subtype, as well as CTLA4, CD276, CD47 and TNFRSF25. Conclusions From the perspective of cell membrane tension, we found that stiff and soft tumor subtypes were closely associated with BCR-free survival for PCa patients, which might be important for the future research in the field of PCa.

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A pan-cancer analysis of the oncogenic role of leucine zipper protein 2 in human cancer

Cited by 19 publications

References 11 publications

Cell type-specific gene expression dynamics during human brain maturation

Cell type-specific gene expression dynamics during human brain maturation

Parkinson’s Disease as a Risk Factor for Prostate Adenocarcinoma: A Molecular Point of View

Membrane tension-mediated stiff and soft tumor subtypes closely associated with prognosis for prostate cancer patients

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