A palm oil–rich diet may reduce serum lipids in healthy young individuals

Ladeia, Ana Marice; Costa-Matos, Eduardo; Barata-Passos, Rodrigo; Guimarães, Armênio Costa

doi:10.1016/j.nut.2007.08.013

Cited by 16 publications

(7 citation statements)

References 13 publications

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“…In human studies, tocotrienol-rich fraction (TRF) derived from rice bran oil or palm oil were associated with reduced oxidative stress in healthy participants,[ 18 19 ] and improved lipid profile in hypercholesterolemic individuals[ 13 ] and patients with diabetes. [ 20 ] The synergistic effect of tocotrienols and lovastatin on lipid profile in hypercholesterolemic humans was also demonstrated.…”

Section: Introductionmentioning

confidence: 99%

Effect of Tocotrienols enriched canola oil on glycemic control and oxidative status in patients with type 2 diabetes mellitus: A randomized double-blind placebo-controlled clinical trial

Vafa¹,

Haghighat²,

Moslehi³

et al. 2015

J Res Med Sci

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Background:Tocotrienols have been shown to improve glycemic control and redox balance in an animal study, but their effects on patients with diabetes are unknown. The study aimed to investigate whether tocotrienols improves glycemic control, insulin sensitivity, and oxidative stress in individuals with type 2 diabetes mellitus (T2DM).Materials and Methods:This study was a double-blinded, placebo-controlled, randomized trial. A total of 50 patients, aged 35-60 years, with T2DM treated by noninsulin hypoglycemic drugs were randomly assigned to receive either 15 mL/day tocotrienols (200 mg) enriched canola oil (n = 25) or pure canola oil (n = 25) for 8 weeks. Fasting blood sugar (FBS), fasting insulin, total antioxidant capacity (TAC), malondialdehyde (MDA), and homeostatic model assessment for insulin resistance (HOMA-IR) were determined before and after the intervention. The data were compared between and within groups, before and after the intervention.Results:Baseline characteristics of participants including age, sex, physical activity, disease duration, and type of drug consumption were not significantly different between the two groups. In tocotrienol enriched canola oil, FBS (mean percent change: –15.4% vs. 3.9%; P = 0.006) and MDA (median percent change: –35.6% vs. 16.3%; P = 0.003) were significantly reduced while TAC was significantly increased (median percent change: 21.4% vs. 2.3%; P = 0.001) compared to pure canola oil. At the end of the study, patients who treated with tocotrienols had lower FBS (P = 0.023) and MDA (P = 0.044) compared to the pure canola oil group. However, tocotrienols had no effect on insulin concentrations and HOMA-IR.Conclusion:Tocotrienols can improve FBS concentrations and modifies redox balance in T2DM patients with poor glycemic control and can be considered in combination with hypoglycemic drugs to better control of T2DM.

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Section: Introductionmentioning

confidence: 99%

Effect of Tocotrienols enriched canola oil on glycemic control and oxidative status in patients with type 2 diabetes mellitus: A randomized double-blind placebo-controlled clinical trial

Vafa¹,

Haghighat²,

Moslehi³

et al. 2015

J Res Med Sci

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“…A positive and significant link between a diet rich in SFA and elevated low-density lipoprotein (LDL) cholesterol and increased risk for cardiovascular disease is widely recognized. However, the scientific evidence for palm oil–rich diets specifically contributing to elevated LDL cholesterol and cardiovascular disease is conflicting [7–10]. …”

Section: Introductionmentioning

confidence: 99%

Palm Oil–Derived Natural Vitamin E α-Tocotrienol in Brain Health and Disease

Sen

Rink

Khanna

2010

Journal of the American College of Nutrition

120

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A growing body of research supports that members of the vitamin E family are not redundant with respect to their biological function. Palm oil derived from Elaeis guineensis represents the richest source of the lesser characterized vitamin E, α-tocotrienol. One of 8 naturally occurring and chemically distinct vitamin E analogs, α-tocotrienol possesses unique biological activity that is independent of its potent antioxidant capacity. Current developments in α-tocotrienol research demonstrate neuroprotective properties for the lipid-soluble vitamin in brain tissue rich in polyunsaturated fatty acids (PUFAs). Arachidonic acid (AA), one of the most abundant PUFAs of the central nervous system, is highly susceptible to oxidative metabolism under pathologic conditions. Cleaved from the membrane phospholipid bilayer by cytosolic phospholipase A2, AA is metabolized by both enzymatic and nonenzymatic pathways. A number of neurodegenerative conditions in the human brain are associated with disturbed PUFA metabolism of AA, including acute ischemic stroke. Palm oil–derived α-tocotrienol at nanomolar concentrations has been shown to attenuate both enzymatic and nonenzymatic mediators of AA metabolism and neurodegeneration. On a concentration basis, this represents the most potent of all biological functions exhibited by any natural vitamin E molecule. Despite such therapeutic potential, the scientific literature on tocotrienols accounts for roughly 1% of the total literature on vitamin E, thus warranting further investment and investigation.

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“…They showed that the consumption of palm oil had led to a significant reduction in the total cholesterol compared with control groups. Ladeia et al [30] also demonstrated in subjects fed on palm oil, a significant reduction in blood cholesterol levels. Zhang et al [31] had assessed the effect of palm oil used in the Chinese diets compared to soybean oil, peanut oil and lard.…”

Section: Lipid and Lipoprotein Parameters Variationsmentioning

confidence: 88%

Effects of Palm Oil Consumption on Lipidic and Lipidoproteinic Profiles in Patients Suffering from Ischemic Heart Pathologies

Absalome¹

2017

IJNFS

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Abstract:Because of its content of saturated fatty acids, palm oil is often considered as being atherogenic nutritionally, and would therefore purveyor of certain diseases including cardiovascular disease. The present study was conducted to assess changes in the lipid profile and lipoprotein of patients with ischemic heart, consumers versus non-consumers of palm oil. The study involved 120 patients enrolled at the Cardiology Institute of Abidjan, divided into 3 groups. Group 1 consisted of 50 patients consumers of refined palm oil, group 2, of 40 patients taking the two forms of oil (refined and raw red), and group 3 comprised 30 patients not consuming palm oil (control group). The lipid parameters and lipoprotein measured were total cholesterol, triglycerides, HDL and LDL cholesterol, and the atherogenic index. In patient's consumers of refined palm oil, after 04 weeks of diet, 58% had normal cholesterol rate, 14% hypercholesterolemia and 28% with low cholesterol rate. As for patients taking both types of palm oil, 57.50% had normal cholesterol rate, 15% hypercholesterolemia and 27.50% with low cholesterol rate. Patients, non-consumers of palm oil had low cholesterol rate at 26.67%. The difference was not significant. Whatever the form of consumption, we notice a variation in the cholesterol rate as well as a tendency of low cholesterol rate after four weeks of dieting, with no significant difference. The same pattern was observed with the dosages of triglycerides, LDL cholesterol, HDL cholesterol and atherogenic index, for which changes were also not significant in the 03 groups. The consumption or not of palm oil, whatever the form and the duration of consumption, had no significant influence on serum lipid and lipoprotein parameters and the atherogenic index of patients carriers of ischemic heart disease. This study, although preliminary, has allowed determining that palm oil is harmless in patients with ischemic heart disease, consumers or non consumers of that oil.

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A palm oil–rich diet may reduce serum lipids in healthy young individuals

Cited by 16 publications

References 13 publications

Effect of Tocotrienols enriched canola oil on glycemic control and oxidative status in patients with type 2 diabetes mellitus: A randomized double-blind placebo-controlled clinical trial

Effect of Tocotrienols enriched canola oil on glycemic control and oxidative status in patients with type 2 diabetes mellitus: A randomized double-blind placebo-controlled clinical trial

Palm Oil–Derived Natural Vitamin E α-Tocotrienol in Brain Health and Disease

Effects of Palm Oil Consumption on Lipidic and Lipidoproteinic Profiles in Patients Suffering from Ischemic Heart Pathologies

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