A pair of particles in inertial microfluidics: effect of shape, softness, and position

Patel, Kuntal; Stark, Holger

doi:10.1039/d1sm00276g

Cited by 25 publications

(23 citation statements)

References 97 publications

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“…While conventional inertial microfluidic applications manipulate soft capsules and solid particles using the inertial lift force (see, for example, Ref. [ 16 ]), in this article we focused on multi-component flows in the inertial regime. Concretely, we studied the motion of a liquid sheet at the center of a microchannel surrounded by a flowing liquid of larger viscosity and monitored its instability towards traveling interfacial waves and droplet breakup.…”

Section: Discussionmentioning

confidence: 99%

“…Their flows at moderate Reynolds numbers enable high throughput and inertial focusing [ 7 , 8 ] in order to develop manipulation techniques for biomedical applications. Motivated by this, a plethora of research has been carried out on inertial microfluidics in the last decade [ 9 – 13 ] including our own studies on the manipulation of soft capsules and solid particles using the inertial lift force [ 14 – 16 ].…”

Section: Introductionmentioning

confidence: 99%

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Instability of a liquid sheet with viscosity contrast in inertial microfluidics

Patel

Stark

2021

Eur. Phys. J. E

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Flows at moderate Reynolds numbers in inertial microfluidics enable high throughput and inertial focusing of particles and cells with relevance in biomedical applications. In the present work, we consider a viscosity-stratified three-layer flow in the inertial regime. We investigate the interfacial instability of a liquid sheet surrounded by a density-matched but more viscous fluid in a channel flow. We use linear stability analysis based on the Orr–Sommerfeld equation and direct numerical simulations with the lattice Boltzmann method (LBM) to perform an extensive parameter study. Our aim is to contribute to a controlled droplet production in inertial microfluidics. In the first part, on the linear stability analysis we show that the growth rate of the fastest growing mode $$\xi ^{*}$$ ξ ∗ increases with the Reynolds number $$\text {Re}$$ Re and that its wavelength $$\lambda ^{*}$$ λ ∗ is always smaller than the channel width w for sufficiently small interfacial tension $$\Gamma $$ Γ . For thin sheets we find the scaling relation $$\xi ^{*} \propto mt^{2.5}_{s}$$ ξ ∗ ∝ m t s 2.5 , where m is viscosity ratio and $$t_{s}$$ t s the sheet thickness. In contrast, for thicker sheets $$\xi ^{*}$$ ξ ∗ decreases with increasing $$t_s$$ t s or m due to the nearby channel walls. Examining the eigenvalue spectra, we identify Yih modes at the interface. In the second part on the LBM simulations, the thin liquid sheet develops two distinct dynamic states: waves traveling along the interface and breakup into droplets with bullet shape. For smaller flow rates and larger sheet thicknesses, we also observe ligament formation and the sheet eventually evolves irregularly. Our work gives some indication how droplet formation can be controlled with a suitable parameter set $$\{\lambda ,t_{s},m,\Gamma ,\text {Re}\}$$ { λ , t s , m , Γ , Re } . Graphical Abstract

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Instability of a liquid sheet with viscosity contrast in inertial microfluidics

Patel

Stark

2021

Eur. Phys. J. E

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“…As illustrated in Figure D, the flow field in the microchannel is evolved by the LBM, while the particle model is constructed using the FEM. The velocity of the flow field node and the force of the particle node are coupled via the IBM to transfer the interaction between particle and fluid. , …”

Section: Methodsmentioning

confidence: 99%

Controllable Size-Independent Three-Dimensional Inertial Focusing in High-Aspect-Ratio Asymmetric Serpentine Microchannels

Zhou

Zhu

et al. 2022

Anal. Chem.

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High-throughput three-dimensional (3D) focusing of cells is the key prerequisite for enabling accurate microfluidic cell detection and analysis. In this work, we develop a high-aspectratio asymmetric serpentine (HARAS) microchannel for single-line inertial focusing of particles and cells at the 3D center of the channel. The mechanism of 3D focusing is explored by numerical simulation, and the focusing performances of differently sized particles are characterized experimentally at different flow rates. The results demonstrate the outstanding 3D single-line focusing capability of our HARAS microchannel. In addition, the phenomena of size-independent and position-controllable focusing over wide flow rates are observed. Finally, the applicability of our HARAS microchannel for processing real biological cells is validated by the 3D single-line focusing of A549 cells and MCF-7 cells. Our work overcomes the issue of off-centered focusing of most previous works and provides new insights into the 3D focusing in inertial microfluidics. The proposed HARAS microchannel is extremely easy for mass production and may provide a stable, high-throughput, and position-controllable scheme for subsequent single-cell detection and analysis.

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“…Here, however, not only the link between shape, material properties (deformability) and fluid dynamics plays a role, but also the influence of the surrounding walls. 8–11…”

Section: Introductionmentioning

confidence: 99%

“…Here, however, not only the link between shape, material properties (deformability) and fluid dynamics plays a role, but also the influence of the surrounding walls. [8][9][10][11] While the literature regarding the dynamics of rigid particles is vast and consolidated, the research and knowledge regarding the dynamics of elastic particles is still incomplete in places and it remains of great interest to the scientific community. 7,12 Even comparatively simple particle dynamics, such as the sedimentation of elastic spheres in an unbounded fluid, is only described in basic theory or is based on numerical calculations.…”

Section: Introductionmentioning

confidence: 99%