A pain in the arms

Catalano, Loredana; Perrone, Antonio; Cecere, Carmela; Sabbà, Carlo

doi:10.1007/s11739-013-1025-8

Cited by 1 publication

(4 citation statements)

References 9 publications

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“…The causes of compartment syndrome can be classified as causes that either increase compartment contents, such as trauma and edema, or restrict compartment volume, such as ill-fitted orthopedic casts [1, 2, 5]. The most common cause of compartment syndrome is trauma, due to fractures, crush or vascular injuries, or severe burns [6]. Spontaneous compartment syndrome can be seen, generally secondary to diabetes mellitus or hypothyroidism among other causes [6].…”

Section: Discussionmentioning

confidence: 99%

“…The most common cause of compartment syndrome is trauma, due to fractures, crush or vascular injuries, or severe burns [6]. Spontaneous compartment syndrome can be seen, generally secondary to diabetes mellitus or hypothyroidism among other causes [6]. The bilateral presentation of ACS points to a systemic etiology [1].…”

Section: Discussionmentioning

confidence: 99%

“…Compartment syndrome develops when the intra-compartmental pressure (ICP) increases until it impedes tissue perfusion [6]. As pressure increases, ischemia and subsequent necrosis occur [1, 6].…”

Section: Discussionmentioning

confidence: 99%

“…As pressure increases, ischemia and subsequent necrosis occur [1, 6]. In patients with hypothyroidism, the volume needed to observe ischemic changes may be much less.…”

Section: Discussionmentioning

confidence: 99%

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Hypothyroid-induced acute compartment syndrome in all extremities

Musielak

Chae

2016

J. surg. case rep.

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Acute compartment syndrome (ACS) is an uncommon complication of uncontrolled hypothyroidism. If unrecognized, this can lead to ischemia, necrosis and potential limb loss. A 49-year-old female presented with the sudden onset of bilateral lower and upper extremity swelling and pain. The lower extremity anterior compartments were painful and tense. The extensor surface of the upper extremities exhibited swelling and pain. Motor function was intact, however, limited due to pain. Bilateral lower extremity fasciotomies were performed. Postoperative Day 1, upper extremity motor function decreased significantly and paresthesias occurred. She therefore underwent bilateral forearm fasciotomies. The pathogenesis of hypothyroidism-induced compartment syndrome is unclear. Thyroid-stimulating hormone-induced fibroblast activation results in increased glycosaminoglycan deposition. The primary glycosaminoglycan in hypothyroid myxedematous changes is hyaluronic acid, which binds water causing edema. This increases vascular permeability, extravasation of proteins and impaired lymphatic drainage. These contribute to increased intra-compartmental pressure and subsequent ACS.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…As pressure increases, ischemia and subsequent necrosis occur [1, 6]. In patients with hypothyroidism, the volume needed to observe ischemic changes may be much less.…”

Section: Discussionmentioning

confidence: 99%

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