A Packaged Ingestible Bio-Pill with 15-Pixel Multiplexed Fluorescence Nucleic-Acid Sensor and Bi-Directional Wireless Interface for In-Vivo Bio-Molecular Sensing

Zhu, Chengjie; Wen, Yuhan; Liu, Tao; Yang, Han‐Kwang; Sengupta, Kaushik

doi:10.1109/vlsicircuits18222.2020.9163060

Cited by 14 publications

(5 citation statements)

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“…coaxial transmission line and terminated with Sub‐Miniature version A (SMA) connector 117 . The connector, transmission line, silver epoxy, and portions of SMA connector have been coated with silicone for the purpose of biologically isolating incompatible materials from the site of the implantation 118 …”

Section: In‐vivo Antenna Architecturementioning

confidence: 99%

A survey on state of the inter body radio communication channel: Performance and solutions

Mezher¹,

Alabbas

Ilyas

2022

Trans Emerging Tel Tech

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The development of in-vivo communications and networking systems has the potential for improving the healthcare delivery while also enabling the creation of new services and applications. In-vivo communications provide wireless networked cyber-physical systems of the embedded devices that enable accurate, quick, and cost-effective responses under a variety of circumstances. Also, it is focused upon modeling and characterizing in-vivo wireless channel, as well as contrasting it to other well-known channels. In this paper, channel coding is also mentioned because it improves data rates and performance gain. This work also discusses present problems and potential research topics for in-vivo communications. This article aims to show the researchers how the orthogonal frequency multiple access (OFDMA) technique improved the performance of in-vivo channel and how it is outperformed compared to the other techniques (TDM, TDMA, CDMA and OFDM) also how the OFDMA outperformed equalizers and channel coding in terms of bit error rate with giving a significant improvement of data transmitting and avoiding inter symbol interference. However, when it comes to the in-vivo communications, the modeling of in-vivo wireless channel is vital.Understanding the features of the in-vivo channel is critical for achieving optimal processing and designing successful procedures that allow WBANs to be arranged inside the human body.

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Section: In‐vivo Antenna Architecturementioning

confidence: 99%

A survey on state of the inter body radio communication channel: Performance and solutions

Mezher¹,

Alabbas

Ilyas

2022

Trans Emerging Tel Tech

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“…In a separate study, an ingestible biomolecular sensing system was developed for the detection of microbiome nucleic acids in the gastrointestinal tract [119]. The device fitted within the FDA-approved capsule size of 000.…”

Section: Capsules For Bacterial Biomarkers and Nucleic Acidsmentioning

confidence: 99%

Video Capsule Endoscopy and Ingestible Electronics: Emerging Trends in Sensors, Circuits, Materials, Telemetry, Optics, and Rapid Reading Software

Miley

Machado

Condo

et al. 2021

Adv Devices Instrum

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Real-time monitoring of the gastrointestinal tract in a safe and comfortable manner is valuable for the diagnosis and therapy of many diseases. Within this realm, our review captures the trends in ingestible capsule systems with a focus on hardware and software technologies used for capsule endoscopy and remote patient monitoring. We introduce the structure and functions of the gastrointestinal tract, and the FDA guidelines for ingestible wireless telemetric medical devices. We survey the advanced features incorporated in ingestible capsule systems, such as microrobotics, closed-loop feedback, physiological sensing, nerve stimulation, sampling and delivery, panoramic imaging with adaptive frame rates, and rapid reading software. Examples of experimental and commercialized capsule systems are presented with descriptions of their sensors, devices, and circuits for gastrointestinal health monitoring. We also show the recent research in biocompatible materials and batteries, edible electronics, and alternative energy sources for ingestible capsule systems. The results from clinical studies are discussed for the assessment of key performance indicators related to the safety and effectiveness of ingestible capsule procedures. Lastly, the present challenges and outlook are summarized with respect to the risks to health, clinical testing and approval process, and technology adoption by patients and clinicians.

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“…Unnecessarily disturbing the wound environment, and limiting wound evaluation to few observable features may contribute to slow healing and the risk of bacterial infection and sepsis [1]. The key technology to minimize the risks is to enable point-of-care diagnostic devices in compact packages, based on integrated circuit technology, such as CMOS (complementary-metal-oxide-semiconductor) [8][9][10]. For chronic wound healing monitoring, such devices are typically packages in the form of "smart bandages".…”

Section: Introductionmentioning

confidence: 99%

Cmos-Nanowell Based Hybrid Smart Bandage for Long Term Monitoring of Wound Healing via Cytokine Quantification in-Situ

Zhu,

Xie,

Thorpe

et al. 2022

2022 Solid-State, Actuators, and Microsystems Workshop Technical Digest

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Long-term monitoring of the chronic wound can allow autonomous wound healing. Prior attempts that sense wound closure dynamics in bandage forms are based on pressure, temperature and pH, lacking specific bio-molecular information that is critical for accurate acquisition of growth factors in various wound healing stages. This work presents a hybrid CMOS/nanowell co-design approach to target cytokine level to predict wound closure dynamics. The complete impedance spectroscopy chip is designed and fabricated in TSMC 65 nm LP process and is integrated on a flexible PCB compatible to "Smart Bandage" forms along with nanowell sensors located at the back and peripheral circuits. The proposed system demonstrates the sensitivity of IL-6 cytokine on the order of 100 pg/mL, and shows strong correlations to the standardized ELISA tests. This proposed CMOS/nano hybrid approach shows a path towards highly multiplexed and low-cost "Smart Bandages" for autonomous closed-loop wound monitoring and healing applications.

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A Packaged Ingestible Bio-Pill with 15-Pixel Multiplexed Fluorescence Nucleic-Acid Sensor and Bi-Directional Wireless Interface for In-Vivo Bio-Molecular Sensing

Cited by 14 publications

References 0 publications

A survey on state of the inter body radio communication channel: Performance and solutions

A survey on state of the inter body radio communication channel: Performance and solutions

Video Capsule Endoscopy and Ingestible Electronics: Emerging Trends in Sensors, Circuits, Materials, Telemetry, Optics, and Rapid Reading Software

Cmos-Nanowell Based Hybrid Smart Bandage for Long Term Monitoring of Wound Healing via Cytokine Quantification in-Situ

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