A. P. Evidencefor a humoral thy-mus factor responsible for the maturation of immunological faculty

Osoba, David; Miller, Jenelle

doi:10.1097/00007890-196401000-00036

Cited by 2 publications

(2 citation statements)

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“…Alternatively, however, a basic defect in stem cell-thymus interaction can be postulated. The essential role of the thymus in the differentiation of the lymphoid stem cell is well recognized (38)(39)(40)(41)(42)(43)(44)(45)(46)(47)(48). However, the stem cell may play an equally important role as a trophic influence for thymus development (49 The costs of publication of this article were defrayed in part by the payment of page charges from funds made available to support the research which is the subject of the article.…”

Section: Discussionmentioning

confidence: 99%

Rationale for combined use of fetal liver and thymus for immunological reconstitution in patients with variants of severe combined immunodeficiency

Pahwa

Good

et al. 1977

Proc. Natl. Acad. Sci. U.S.A.

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Bone marrow cells from a patient with severe combined immunodeficiency were studied in vitro for thymus-dependent lymphocyte (T cell) Severe combined immunodeficiency disease (SCID) is a diagnostic term for a heterogeneous group of congenital disorders usually ascribed to a defect in the development or function of lymphoid stem cells (1). Such patients usually have defective development and function of both thymus-dependent lymphocyte (T cell) and thymus-independent lymphocyte (B cell) populations (2). Immunologic reconstitution in patients with this disease has been repeatedly achieved after transplantation of marrow from related, histocompatible donors (3)(4)(5)(6)(7)(8) In this report, we present evidence to indicate that, in certain variants of SCID, transplantation of both fetal liver and thymus may be necessary to provide both the stem cell and an inductive influence necessary for immunologic reconstitution. MATERIALS AND METHODSCase Report. The patient, a 20-month-old white boy, was a full-term 3.8-kg product of a normal pregnancy. Growth and development were normal until age 10 weeks, at which time a monilial rash was first noted behind his right ear; this was followed by severe oral moniliasis at age 4 months. Both conditions were refractory to antifungal therapy. At 5 months of age, poor feeding and progressive weight loss developed. On Sept., 18, 1975, at age 7 months, he was admitted to our hospital.At the time of admission, the patient was markedly cachectic, weighed 5.5 kg, and had severe moniliasis involving the oral cavity and perineal area. Clinical and roentgenographic evidence of interstitial pneumonia, subsequently documented to be due to Pneumocystis carinii, was noted. No

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Section: Discussionmentioning

confidence: 99%

Rationale for combined use of fetal liver and thymus for immunological reconstitution in patients with variants of severe combined immunodeficiency

Pahwa

Good

et al. 1977

Proc. Natl. Acad. Sci. U.S.A.

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“…1) advantage was taken of the ability of macrophages to stick to glass or to plastic surfaces. The method described by Mosier and Coppleson (10) was adopted in which spleen cells (1)(2)(3)(4)(5) x 107/ml from pooled spleen cell suspensions) were cultured in Petri dishes for 30 min at 37" on the rocking platform. Those cells remaining free in the culture medium were designated the nonadherent population.…”

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confidence: 99%