A Overview on Nanosponges

Gole, Vaishnavi G.; Patwekar, S. L.; Doiphode, Ankush; Rode, Ashwini; Shaikh, Suleman

doi:10.52711/2231-5659.2022.00037

AJPS

2022

DOI: 10.52711/2231-5659.2022.00037

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A Overview on Nanosponges

Vaishnavi G. Gole

S. L. Patwekar

Ankush Doiphode

et al.

Abstract: The solid porous particles have a nanocavity structure in which drugs are encapsulated known as nanosponges. There are five types of nanosponges. Nanosponges size varies from 1um and less than 1 um. Nanosponges are stable at high temperatures. It has high drug loading capacity. Nanosponges formulation overcomes stability, delayed-release activity, and solubility-related problems. Nanosponges can deliver the drug through oral, parenteral, and topical routes. The current review focuses on nanosponges in drug del… Show more

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A Review on Nanosponges and Polymers Used in Their Production

Swarnalatha¹,

Singh²,

Reddy³

et al. 2023

ijsr

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Nanosponges are a novel targeted drug delivery technology. Nanosponges are cross-linked polymers that are nanostructured within a threedimensional network. They are mainly used as controlled drug delivery systems for pharmaceutical applications. In cancer applications, these nanosponges complexes are drug-loaded and release targeting peptides that are tightly bound to the radiation-induced cell surface layer of tumour receptors. Upon contact, the nanosponges adhere to the surface of tumour cells and begin to release drug molecules. Nanosponges also have the potential for the treatment of SARS-CoV-2. Such nanosponges are derived from membranes of human cells/tissues that are naturally attacked by SARS-CoV-2. These nanosponges can bind and destroy viruses and induce clinical improvement through cytokine neutralization. Thus nanosponges can successfully protect hosts from any kind of invading cells

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A Review on Nanosponges and Polymers Used in Their Production

Swarnalatha¹,

Singh²,

Reddy³

et al. 2023

ijsr

View full text Add to dashboard Cite

show abstract

Formulation and Evaluation of Nanosponge-based Drug Delivery System of Aceclofenac for Topical application

Gupta,

Shrivastava,

Ghuge

et al. 2023

RJPT

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A transdermal drug delivery system using nanosponge and BCS class II drug, Aceclofenac (ACE) was achieved using xerogel as a final dosage form. Blank Beta Cyclodextrin based nanosponge (CDNS) were loaded with aceclofenac to formulate ACE loaded CDNS not only can be effectively treated for osteoarthritis but also successfully evaluated using ex vivo skin permeation studies. Methods used for formulation of ACE loaded CDNS were found out to be effective and accomplished 89.29±2.59% drug entrapment. The optimized formulation had % drug loading of 72.16±3.13%. The zeta potential of the ACE-loaded CDNS was found to be -27.3±1.1mV. A zeta potential value close to ±30mV indicates good physical stability of the micro particles on account of electrostatic repulsion. ACE-loaded CDNS released more than 90% drug in just 150mins (2.5hrs) whereas the marked formulation and ACE drug released more than 90% drug in 240mins (4hrs) and 330mins (5.5hrs) respectively. The conclusion of the current work can be drawn as ACE-loaded CDNS based gel has the potential to improve the transdermal bioavailability of aceclofenac against osteoarthritis with less adverse actions.

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A Overview on Nanosponges

Cited by 2 publications

References 15 publications

A Review on Nanosponges and Polymers Used in Their Production

A Review on Nanosponges and Polymers Used in Their Production

Formulation and Evaluation of Nanosponge-based Drug Delivery System of Aceclofenac for Topical application

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