A one-step synthesized acridine-based fluorescent chemosensor for selective detection of copper(ii) ions and living cell imaging

Abstract

A highly selective and sensitive fluorescence quenching chemosensor (ACC) for Cu2+ detection in HEPES buffer and living cell imaging was developed.

Simultaneous Detection of Cu2+ and Co2+ by a Water‐Soluble Carboxamide‐Based Colorimetric Chemosensor

“…1 H NMR titration was performed to comprehend the interaction of ATA‐Msal and Cu 2+ (Figure S6). When Cu 2+ solution (1 equiv) was added to ATA‐Msal, all the protons of ATA‐Msal were remarkably decreased due to the paramagnetic properties of Cu 2+ and shifted to upfield . In particular, the proton of phenol O−H was shifted from 10.79 ppm to 10.27 ppm, and the imine proton at 9.04 ppm and the amide protons at 8.09 and 7.70 ppm disappeared.…”

A Pentapeptide with Tyrosine Moiety as Fluorescent Chemosensor for Selective Nanomolar-Level Detection of Copper(II) Ions

“…One of the most probable reasons responsible for the observed phenomenon is the formation of a nonfluorescent Cu 2+ -peptide complex due to a chelation enhancement quenching effect [33] or/and ligand to metal charge transfer [34][35][36]. The presence of a paramagnetic d 9 Cu 2+ ion in the proximity of a tyrosine residue makes that, in each complex, the forbidden intersystem crossing becomes faster (paramagnetic effect) [17,33]. As a result, the studied complexes after excitation undergo intersystem crossing from S 1 to T 1 state of the fluorophore that is further deactivated by bimolecular non-radiative processes.…”

“…Although all these methods provide relatively low limits of detection and wide concentration ranges, many of them are destructive techniques that require the use of expensive equipment, making them not adaptable for online monitoring. Therefore, the development of fluorescent chemosensors (due to high sensitivity of fluorescence spectroscopy, easy operation, visual simplicity [14], instantaneous response, real-time detection [15], and a variety of fluorophores [16]) for the detection of Cu 2+ ions is of great importance [17]. On the other hand, the availability of a variety of fluorophores and the selectivity of such fluorescent probes still remain a great challenge, as many recently reported chemosensors for cations demonstrated a change in their fluorescent features after binding with more than one ion [18][19][20].…”

A colorimetric chemosensor for selective detection of copper ions

“…To further study the binding interaction of HMB to Cu( ii ), NMR titration was carried out (Figure S5). Upon the addition of Cu( ii ), the proton peaks of HMB diminished due to the paramagnetic properties of Cu( ii ), 51 indicating that HMB completely interacted with Cu( ii ). With Job plot analysis, ESI‐MS and NMR titration, the appropriate structure of HMB‐Cu( ii ) was suggested (Scheme 2).…”