A one-pot, three-component synthesis of thiazolidine-2-thiones

Dithiocarbamates as an Efficient Intermediate for the Synthesis of Symmetrical Substituted 2,5‐Diamino‐1,3,4‐thiadiazoles in Water

“…As the biological activity of thiadiazoles are depending on the type of modification in the ring, and in continuation of our research on dithiocarbamates, we were interested in the synthesis of a range of symmetrical 2,5‐disubstituted amino‐1,3,4‐ thiadiazoles under mild reaction conditions with the reaction of dithiocarbamates with hydrazine salt (Scheme 1). For this purpose, we have synthesized the starting materials by the reaction of aromatic amines, carbon disulfide, alkyl halide or acrylonitrile in the presence of triethylamine . After synthesizing of the starting materials, we focused on the optimization of the reaction conditions by varying the ratio of the starting materials, pyridine or triethyl amine as promoter, temperature, and the solvent.…”

Novel Synthesis of Tryptamine Derived 4‐Hydroxy‐4‐arylthiazolidine‐2‐thiones and 4‐Arylthiazole‐2(3H)‐thiones by Multicomponent Reactions

“…Recently, three component one‐pot synthesis of 3,4‐disubstituted thiazolidine‐2‐thione derivatives, 4,5‐disubstituted‐3‐amino‐4‐hydroxy‐thiazolidine‐2‐thiones, 5‐(iodomethyl)‐thiazolidine‐2‐thiones, and 1,3‐thiazolidine‐2‐thiones, have been well documented. Hantzsch method is the most frequently used template for synthesis of thiazoles which involves cyclization and condensation of haloketones with thioamide .…”

Multimetallic Complexes and Functionalized Nanoparticles Based on Unsymmetrical Dithiocarbamate Ligands with Allyl and Propargyl Functionality

“…This compares well to leading literature routes, such as the iodocyclization of allyl amines, which generates two moles of HI and proceeds in yields of 46-75%. 12 The extension of this route to other propargylamine substrates falls outside the scope of this project but could provide a valuable additional route to such heterocycles. While this reaction is an unexpected and interesting observation, it does limit the utility of 7 as a reagent.…”