A one-dimensional random laser based on artificial high-index contrast scatterers

Wu, Yanyan; Ren, Yuhao; Chen, Anqi; Chen, Ziyang; Liang, Yun-Feng; Li, JinYu; Lou, Guanlin; Zhu, Hai; Gui, Xuchun; Wang, Shuangpeng; Tang, Zikang

doi:10.1039/c7nr00261k

Cited by 16 publications

(10 citation statements)

References 39 publications

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“…It is observed that the lasing wavelength of BFRL filled with MCF-7 cells has a 2.3 ± SE 0.2 nm blue shift with respect to that with MDA-MB-231 cells. This lasing wavelength shift phenomenon has been observed in previous studies, wherein the scattering strength of the random laser system is variable. ,,− The corresponding mechanism can be illustrated on the basis of the analysis of another important biophysical property, the refractive index. For example, Hu et al shows that the 0.011 refractive index variation could result in a spectral shift of up to 18.5 nm .…”

Section: Resultssupporting

confidence: 60%

Biofluidic Random Laser Cytometer for Biophysical Phenotyping of Cell Suspensions

Ren

et al. 2019

ACS Sens.

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Phenotypic profiling of single floating cells in liquid biopsies is the key to the era of precision medicine. Random laser in biofluids is a promising tool for the label-free characterization of the biophysical properties due to the high brightness and sharp peaks of the lasing spectra, yet previous reports were limited to the random laser in solid tissues with dense scatterings. In this report, a random laser cytometer is demonstrated in an optofluidic device filled with gain medium and human breast normal/cancerous cells. The multiple light scattering induced by the micro-scale human cells promotes the random lasing and influences the lasing properties in term of laser modes, spectral wavelengths, and lasing thresholds. A sensing strategy based on analyzing the lasing properties to determine both the whole-cell and the subcellular biophysical properties of the cells and the malignant alterations of the cell suspensions are successfully detected. Our results provide a new approach to designing a label-free biophysical cytometer based on optofluidic random laser devices, which is advantageous for further research in the field of random laser bio-application.

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Section: Resultssupporting

confidence: 60%

Biofluidic Random Laser Cytometer for Biophysical Phenotyping of Cell Suspensions

Ren

et al. 2019

ACS Sens.

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“…Reducing the size of a random laser to microscale opens up many potential applications such as on‐chip optical communications, data processing, and biointegration. [ 13 ] To date, random microlasers are highly limited to semiconductor‐based structure such as the clusters of ZnO nanoparticles, [ 14 ] and ZnO microwires [ 15 ] whereas organic random lasers generally have a larger size in a range of millimeter scale. [ 16–18 ] Compared with semiconductor random microlasers, organic random microlasers may have several advantages including low‐cost fabrication, flexible properties, and lightweight.…”

Section: Introductionmentioning

confidence: 99%

Biocompatible Polymer and Protein Microspheres with Inverse Photonic Glass Structure for Random Micro‐Biolasers

Caixeiro

Saxena

et al. 2021

Advanced Photonics Research

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The miniaturization of random lasers to the micrometer scale is challenging but fundamental for the integration of lasers with photonic integrated circuits and biological tissues. Herein, it is demonstrated that random lasers with a diameter from 30 to 160 μm can be achieved by using a simple emulsion process and selective chemical etching. These tiny random laser sources are made of either dye‐doped polyvinyl alcohol (PVA) or bovine serum albumin (BSA) and they are in the form of microporous spheres with monodisperse pores of 1.28 μm in diameter. Clear lasing action is observed when the microporous spheres are optically excited with powers larger than the lasing threshold, which is 154 μJ mm−2 for a 75 μm diameter PVA microporous sphere. The lasing wavelength redshifts 10 nm when the PVA microsphere diameter increases from 34 to 160 μm. For BSA microspheres, the lasing threshold is around 55 μJ mm−2 for a 70 μm diameter sphere and 104 μJ mm−2 for a 35 μm diameter sphere. The simple fabrication process reported allows for detail studies of morphology and size, important for fundamental studies of light–matter interaction in complex media, and applications in photonic integrated circuits, photonic barcoding, and optical biosensing.

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“…Although these defect-related micropits were considered destructive for electron transport, , they have a strong scattering feedback effect for light propagation in the MW. Especially, the scattering feedback from the micropits can localize the light field and form localized paths to construct the RL action . A schematic diagram of the localized paths on RL in the MW is illustrated in Figure c.…”

Section: Results and Discussionmentioning

confidence: 99%

“…Although an RL has been observed in GaN nanocolumns, particles, and epitaxy films, , the manipulation of the lasing mode and output divergence is a great challenge for two- and three-dimensional disorder media. Recently, the manipulation of the RL mode in a one-dimensional microwire (MW) may open a new horizon of optimization for GaN RLs …”

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confidence: 99%

Ultraviolet Random Laser Based on a Single GaN Microwire

Ren

Zhu

et al. 2018

ACS Photonics

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Random lasing (RL) from self-constructed localized cavities based on micropits scatters in a single GaN microwire (MW) was investigated. The spectra and spatial resolution of RL exhibits that the lasing modes originated from different regions in the MW. Temperature-dependent lasing measurement of GaN RL shows an excellent characteristic temperature of about 52 K. In addition, the dependence of spatial localized cavities’ dimension on the pumping intensity profile and temperature was studied by fast Fourier transform spectroscopy. For GaN RL, the optical feedback was supported by localized paths through the scattering effect of micropits in the MW. The scattering feedback mechanism for RL can avoid the enormous difficulty in fabricating artificial cavity structures for GaN. Hence, the results in this paper represent a low-cost technique to realize GaN-based ultraviolet laser diodes without the fabrication difficulty of cavity facets.

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A one-dimensional random laser based on artificial high-index contrast scatterers

Cited by 16 publications

References 39 publications

Biofluidic Random Laser Cytometer for Biophysical Phenotyping of Cell Suspensions

Biofluidic Random Laser Cytometer for Biophysical Phenotyping of Cell Suspensions

Biocompatible Polymer and Protein Microspheres with Inverse Photonic Glass Structure for Random Micro‐Biolasers

Ultraviolet Random Laser Based on a Single GaN Microwire

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