A One-Dimensional Phase-Modulated (PM) NMR Experiment for Differentiating Spin Systems in Small Molecules Mixtures: With Application to Chiral Discrimination and Bicomponent Organic Systems

Abstract

A one-dimensional phase-modulated NMR experiment, which distinguishes the partially resolved peaks and accelerates the data acquisition due to reduced dimensionality, is reported for differentiating spin systems, with application to chiral discrimination. The multifarious utility of the technique is demonstrated in plenteous examples.

Quantitative NMR spectroscopy of complex mixtures

“…38 More recently, selective rather than broadband decoupling methods have been suggested for enantiodiscrimination, offering a more sensitive -although less general-analysis than pure-shift NMR. 32,39 Another field where several methodological advances have enabled new applications is the quality control of complex drug mixtures, with heparin as a common example (Fig. 1B).…”

“…38 More recently, selective rather than broadband decoupling methods have been suggested for enantiodiscrimination, offering a more sensitive -although less general-analysis than pure-shift NMR. 32,39…”